血管活性肠肽（VIP）对绵羊淋巴细胞运输的抑制作用。
Depression of lymphocyte traffic in sheep by vasoactive intestinal peptide (VIP).
作者信息
Moore T C, Spruck C H, Said S I
机构信息
Department of Surgery, UCLA School of Medicine, Torrance 90509.
出版信息
Immunology. 1988 Jul;64(3):475-8.
Vasoactive intestinal peptide (VIP) is a 28 amino acid-residue neurovascular and gut peptide with a number of important biological activities. Recent in vitro studies suggest an immunomodulatory (depressant) role for VIP. In the present in vivo studies, employing the Hall and Morris sheep lymphocyte traffic model, acute infusions of VIP into cannulated afferent lymphatics of popliteal lymph nodes produced prompt and marked depressions in the output of both small recirculating and blast lymphocytes into popliteal efferent lymph, with a selective effect on T4 (CD4) lymphocytes. It has been suggested that the HIV (AIDS) virus may employ VIP or VIP-like receptors on brain cells and lymphocytes for intracellular access.
血管活性肠肽（VIP）是一种由28个氨基酸残基组成的神经血管和肠道肽，具有多种重要的生物学活性。最近的体外研究表明，VIP具有免疫调节（抑制）作用。在目前的体内研究中，采用霍尔和莫里斯绵羊淋巴细胞运输模型，将VIP急性注入腘淋巴结的插管传入淋巴管，可使小循环淋巴细胞和母细胞向腘传出淋巴的输出迅速且显著降低，对T4（CD4）淋巴细胞有选择性作用。有人提出，HIV（艾滋病）病毒可能利用脑细胞和淋巴细胞上的VIP或类VIP受体进入细胞内。
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