Nuclear Medicine, University of Brescia and ASST Spedali Civili Brescia, Brescia, Italy.
Nuclear Medicine, ASST Spedali Civili Brescia, Brescia, Italy.
Br J Radiol. 2021 Jul 1;94(1123):20200672. doi: 10.1259/bjr.20200672. Epub 2021 Jun 9.
High-dose CT (HDCT) is considered the gold-standard imaging for the measurements of skeletal muscle area (SMA), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and intramuscular adipose tissue (IMAT) areas in the abdomen. These parameters may reflect sarcopenia, which can have a prognostic impact in several oncological diseases. The aim of this study was to compare the agreement of measurements of SMA, VAT, SAT and IMAT areas between HDCT and low-dose CT (LDCT) of 18-fludeoxyglucose positron emission tomography (F-FDG PET)/CT in elderly patients affected by Hodgkin lymphoma (HL).
We retrospectively included 90 patients affected by HL who underwent baseline F-FDG-PET/CT and HDCT within a mean interval of 7 days. HDCT and LDCT images were analysed by two blinded observers using segmentation software (Slice-O-Matic, Tomovision) to quantify the areas. HDCT and LDCT measurements were compared using Bland-Altman plots and Passing-Bablock regression analyses. Pearson correlation coefficient (r) was used to correlate measurements from the two imaging modalities.
Comparison of HDCT and LDCT data demonstrated a strong correlation for measurement of VAT( = 0.942, < 0.0001), SAT ( = 0.894, < 0.0001) and SMA ( = 0.934, < 0.0001). Instead considering IMAT, correlation was good but less significant ( = 0.742). The mean difference between the two methods was found to be very small, with a difference of 1% for SAT,+6.1% for VAT,+2.5% for SMA and -1.9% for IMAT.
LDCT of PET/CT is a safe, accurate and precise method for the measurements of skeletal muscle area, visceral and subcutaneous adipose tissue. Their measurements are reproducible and correlate closely with HDCT.
LLDCT of PET/CT is a safe and accurate method for the measurements of SMA, VAT and SAT; their measurements are closely correlated with HDCT. LDCT can be considered an accurate alternative tool for measuring abdominal fat and muscles in the clinical practice.
高剂量 CT（HDCT）被认为是测量腹部骨骼肌面积（SMA）、内脏脂肪组织（VAT）、皮下脂肪组织（SAT）和肌内脂肪组织（IMAT）的金标准成像方法。这些参数可能反映出肌肉减少症，这在多种肿瘤疾病中具有预后影响。本研究的目的是比较 HDCT 和低剂量 CT（LDCT）在 18-氟脱氧葡萄糖正电子发射断层扫描（F-FDG PET）/CT 检查的老年霍奇金淋巴瘤（HL）患者中的 SMA、VAT、SAT 和 IMAT 区域测量的一致性。
我们回顾性纳入了 90 名接受基线 F-FDG-PET/CT 和 HDCT 的 HL 患者，两次检查的平均间隔为 7 天。两名观察者使用分割软件（Slice-O-Matic、Tomovision）对 HDCT 和 LDCT 图像进行分析，以量化面积。使用 Bland-Altman 图和 Passing-Bablock 回归分析比较 HDCT 和 LDCT 测量值。使用 Pearson 相关系数（r）比较两种成像方式的测量值。
HDCT 和 LDCT 数据比较显示，VAT（r=0.942，<0.0001）、SAT（r=0.894，<0.0001）和 SMA（r=0.934，<0.0001）的测量具有很强的相关性。而考虑到 IMAT，相关性较好但不显著（r=0.742）。两种方法之间的平均差异很小，SAT 为+1%，VAT 为+6.1%，SMA 为+2.5%，IMAT 为-1.9%。
PET/CT 的 LDCT 是一种安全、准确和精确的方法，可用于测量骨骼肌面积、内脏和皮下脂肪组织。其测量值具有可重复性，与 HDCT 密切相关。
PET/CT 的 LDCT 是一种安全、准确的 SMA、VAT 和 SAT 测量方法；它们的测量值与 HDCT 密切相关。LDCT 可在临床实践中作为测量腹部脂肪和肌肉的准确替代工具。
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