Nuclear Medicine, University of Brescia and Spedali Civili Brescia, Brescia, Italy.
Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Leuk Lymphoma. 2020 Dec;61(13):3209-3216. doi: 10.1080/10428194.2020.1797012. Epub 2020 Jul 24.
Hodgkin lymphoma (HL) has a bimodal age distribution curve, with a second peak in people aged more than 60 years. Interim PET/CT (iPET/CT) is highly predictive for PFS and OS in young HL, but it has not been sufficiently studied in the elderly. In this retrospective dual-center study, 82 patients with HL and aged 65 or more who performed iPET/CT were included. At iPET/CT, 60 patients had a complete metabolic response, 18 partial responses, and 4 progressions of disease. Baseline PET/CT metabolic features were not significantly correlated with the metabolic response at interim. In patients with interim complete metabolic response, PFS and OS were significantly longer than in patients without complete response( < 0.001 and = 0.004). Patients with negative iPET had 2-year PFS and OS rates of 57 and 88% compared with 24 and 58% in patients with positive iPET ( < 0.001). iPET/CT results demonstrated to be independent prognostic factors for PFS and OS.
霍奇金淋巴瘤（HL）的年龄分布呈双峰曲线，60 岁以上人群有第二个发病高峰。在年轻的 HL 患者中，中期 PET/CT（iPET/CT）对 PFS 和 OS 具有高度预测性，但在老年人中尚未得到充分研究。在这项回顾性的双中心研究中，纳入了 82 名年龄在 65 岁及以上且接受 iPET/CT 的 HL 患者。在 iPET/CT 中，60 例患者完全代谢缓解，18 例部分缓解，4 例疾病进展。基线 PET/CT 代谢特征与中期的代谢反应无显著相关性。在中期完全代谢缓解的患者中，PFS 和 OS 明显长于无完全缓解的患者（ < 0.001 和 = 0.004）。阴性 iPET 的患者 2 年 PFS 和 OS 率分别为 57%和 88%，而阳性 iPET 的患者为 24%和 58%（ < 0.001）。iPET/CT 结果被证明是 PFS 和 OS 的独立预后因素。
