Harvey J W, Taboada J, Lewis J C
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.
J Am Vet Med Assoc. 1988 Jun 15;192(12):1751-2.
Babesia canis infection was diagnosed in a litter of seven 3-week-old Mastiff pups kept in a north Florida kennel. The pups were evaluated because of poor weight gain; the smallest pup also was markedly lethargic. Six of the pups were anemic and thrombocytopenic. A positive linear correlation between PCV and absolute reticulocyte count suggested that the variation in PCV may have been related more to the ability of a pup to increase erythrocyte production than to a difference in magnitude of erythrocyte destruction. All pups recovered from clinical signs and hematologic abnormalities attributable to babesiosis within 2.5 weeks after treatment with diminazene aceturate. Transient neurologic signs observed in 1 pup 3 days after treatment were believed to represent an adverse drug reaction. The dam of the litter had a serum titer of 1:640 for B canis, but appeared healthy, as did approximately 30 other adult dog in the kennel. The strain of B canis infecting dogs in the kennel caused severe illness and death in some pups, but clinically inapparent disease in adult dogs.
在佛罗里达州北部一个犬舍饲养的一窝7只3周大的獒犬幼犬中诊断出犬巴贝斯虫感染。这些幼犬因体重增加不佳而接受评估；最小的幼犬也明显无精打采。其中6只幼犬贫血且血小板减少。红细胞压积（PCV）与绝对网织红细胞计数之间呈正线性相关，这表明PCV的变化可能更多地与幼犬增加红细胞生成的能力有关，而不是与红细胞破坏程度的差异有关。在用乙酰马嗪治疗后的2.5周内，所有幼犬均从由巴贝斯虫病引起的临床症状和血液学异常中恢复。1只幼犬在治疗后3天出现的短暂神经症状被认为是药物不良反应。这窝幼犬的母犬犬巴贝斯虫血清滴度为1:640，但看起来健康，犬舍中大约30只其他成年犬也是如此。感染犬舍中犬只的犬巴贝斯虫菌株在一些幼犬中引起了严重疾病和死亡，但在成年犬中临床上表现为不明显的疾病。
