Jacobson L S, Reyers F, Berry W L, Viljoen E
Department of medicine, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
J S Afr Vet Assoc. 1996 Jun;67(2):77-82.
It has been suggested that the antibabesial drug diminazene causes a rapid decline in haematocrit after treatment of dogs with high Babesia canis parasitaemias, compared with trypan blue. To test this, 19 dogs with clinically mild to moderate, uncomplicated babesiosis were placed in low, moderate or high parasitaemia groups, based on venous parasitaemias, and were allotted randomly to diminazene or trypan blue treatment groups. Haematocrit and parasitaemia were determined before treatment, and at 2, 6, 12, 18 and 24 hours. The drugs were compared for effects on haematocrit and parasite clearance. Changes in haematocrit after treatment were analysed. There were no significant differences between diminazene and trypan blue for haematocrit or parasite clearance. There was no correlation between initial parasitaemia and initial or post-treatment haematocrit. In all dogs, haematocrit fell following treatment. The maximum mean reduction from the baseline (0 h) was 0.046 l/l (range 0.02-0.07 l/l); this most often occurred at 6 or 12 h. The 24 h haematocrit ranged from 70.5-113.6% of baseline (mean absolute haematocrit 0.019 l/l below baseline). All dogs improved clinically during the study period. It was concluded that either diminazene or trypan blue can be safely used to treat dogs with clinically mild or moderate, uncomplicated babesiosis. Parasitaemia need not be taken into account when deciding which antibabesial drug to administer and does not appear to be related to the degree of anaemia.
有人提出，与锥虫蓝相比，抗巴贝斯虫药物地克珠利在治疗犬巴贝斯虫犬亚种高寄生虫血症后会导致血细胞比容迅速下降。为了验证这一点，根据静脉寄生虫血症，将19只临床症状为轻度至中度、无并发症的巴贝斯虫病犬分为低、中、高寄生虫血症组，并随机分配到地克珠利或锥虫蓝治疗组。在治疗前以及治疗后2、6、12、18和24小时测定血细胞比容和寄生虫血症。比较这两种药物对血细胞比容和寄生虫清除的影响。分析治疗后血细胞比容的变化。地克珠利和锥虫蓝在血细胞比容或寄生虫清除方面没有显著差异。初始寄生虫血症与初始或治疗后血细胞比容之间没有相关性。所有犬在治疗后血细胞比容均下降。与基线（0小时）相比，最大平均降低值为0.046升/升（范围为0.02 - 0.07升/升）；这最常发生在6或12小时。24小时血细胞比容范围为基线的70.5 - 113.6%（平均绝对血细胞比容比基线低0.019升/升）。在研究期间所有犬的临床症状均有改善。得出的结论是，地克珠利或锥虫蓝均可安全用于治疗临床症状为轻度或中度、无并发症的巴贝斯虫病犬。在决定使用哪种抗巴贝斯虫药物时无需考虑寄生虫血症，且寄生虫血症似乎与贫血程度无关。
