Department of Neurology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Department of Public Health, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Curr Neurovasc Res. 2021;18(2):237-243. doi: 10.2174/1567202618666210607151518.
The role of inflammation in the prognosis of cerebral venous sinus thrombosis (CVST) has been demonstrated in a small number of studies. The platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and the systemic immune-inflammatory index (SII) have been studied as prognostic inflammatory biomarkers in numerous thrombo-embolic diseases. However, the number of studies evaluating the relationship between these parameters and CVST is very low.
The purpose of this retrospective study was to investigate the relationship between PLR, NLR, and SII values on admission and long-term prognosis in patients with CVST in the acute-subacute period.
Fifty-one patients diagnosed with CVST and 51 healthy controls were included in the study. The patient and control groups were compared in terms of NLR, PLR, and SII values. Patients were classified into good and poor prognosis groups based on sixth-month modified Rankin scale scores (mRS) (0-2: good prognosis, 3-6: poor prognosis). Clinical and radiological features and PLR, NLR, and SII values were compared between the good and poor prognosis groups. Multivariate logistic regression analysis was used to identify independent prognostic factors for poor prognosis. The Receiver Operating Curve (ROC) was used to demonstrate the predictive power of PLR, NLR, and SII.
Higher NLR and SII emerged as independent factors for poor prognosis in patients with CVST. NLR was the strongest parameter in predicting poor prognosis in CVST (AUC: 0.817, 95% CI: 0.63-1.00, sensitivity 70%, specificity 92.7%, p:0.002).
Higher NLR and SII on admission may be a predictor of long-term poor prognosis in patients with acute-subacute CVST.
炎症在脑静脉窦血栓形成（CVST）预后中的作用已在少数研究中得到证实。血小板与淋巴细胞比值（PLR）、中性粒细胞与淋巴细胞比值（NLR）和全身免疫炎症指数（SII）已在许多血栓栓塞性疾病中被研究作为预后炎症生物标志物。然而，评估这些参数与 CVST 之间关系的研究数量非常少。
本回顾性研究的目的是探讨急性-亚急性期 CVST 患者入院时 PLR、NLR 和 SII 值与长期预后的关系。
本研究纳入了 51 例确诊为 CVST 的患者和 51 名健康对照者。比较了 NLR、PLR 和 SII 值在患者组和对照组之间的差异。根据第六个月改良 Rankin 量表评分（mRS）（0-2：预后良好，3-6：预后不良）将患者分为预后良好和预后不良组。比较了预后良好和预后不良组之间的临床和影像学特征以及 PLR、NLR 和 SII 值。采用多变量逻辑回归分析识别预后不良的独立预测因素。采用Receiver Operating Curve（ROC）分析评估 PLR、NLR 和 SII 的预测能力。
较高的 NLR 和 SII 是 CVST 患者预后不良的独立因素。NLR 是预测 CVST 预后不良的最强参数（AUC：0.817，95%CI：0.63-1.00，敏感性 70%，特异性 92.7%，p：0.002）。
急性-亚急性 CVST 患者入院时较高的 NLR 和 SII 可能是长期预后不良的预测指标。
