Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University, Columbus, OH, USA.
Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA.
Cell Biochem Biophys. 2021 Sep;79(3):493-496. doi: 10.1007/s12013-021-00993-y. Epub 2021 Jun 10.
The bio-active lipid, lysophosphatidic acid (LPA) interacts with various lysophosphatidic acid receptors (LPARs) to affect a variety of cellular functions, including proliferation, differentiation, survival, migration, morphogenesis and others. The Rho family of small GTPases, is well-known downstream signaling pathways activated by LPA. Among the Rho GTPases, RhoA, Rac1, and Cdc42 are best characterized and LPA-induced activation of the GTPases RhoA, Rac1, and Cdc42 influences a wide range of cellular processes and functions such as cell differentiation, contractile movements, cellular migration, or infiltration. In this review, we will briefly discuss the interplay between LPA and each of these three Rho family proteins, summarizing the main interactions between them. Our discussion will focus mainly on their interplay within lung endothelial and epithelial cells, drawing attention to how these interactions may contribute to pro-inflammatory processes.
生物活性脂质溶血磷脂酸（LPA）与各种溶血磷脂酸受体（LPAR）相互作用，影响多种细胞功能，包括增殖、分化、存活、迁移、形态发生等。Rho 家族的小 GTPases 是 LPA 激活的著名下游信号通路。在 Rho GTPases 中，RhoA、Rac1 和 Cdc42 的特征最为明显，LPA 诱导的 RhoA、Rac1 和 Cdc42 的 GTPases 激活影响广泛的细胞过程和功能，如细胞分化、收缩运动、细胞迁移或浸润。在这篇综述中，我们将简要讨论 LPA 与这三种 Rho 家族蛋白中的每一种之间的相互作用，总结它们之间的主要相互作用。我们的讨论将主要集中在它们在肺内皮细胞和上皮细胞中的相互作用上，关注这些相互作用如何有助于促炎过程。
