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Patient variability in severity of COVID-19 disease. Main suspect: vascular endothelium.

作者信息

Tricarico Gerardo, Travagli Valter

机构信息

COVID1 Unit, Presidio Ospedaliero Sant'Andrea, Vercelli, Italy; UCM United Campus of Malta, UCM Higher Education Institution Foundation, Msida, Malta.

Dipartimento di Biotecnologie, Chimica e Farmacia-Dipartimento di Eccellenza Nazionale, Università degli Studi di Siena, Siena, Italy.

出版信息

J Allergy Clin Immunol Pract. 2021 Jun;9(6):2540-2541. doi: 10.1016/j.jaip.2021.02.063.

DOI:10.1016/j.jaip.2021.02.063
PMID:34112484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8181597/
Abstract
摘要

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本文引用的文献

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Why Do Some People Develop Serious COVID-19 Disease After Infection, While Others Only Exhibit Mild Symptoms?为什么有些人在感染 COVID-19 后会发展成严重疾病，而有些人则只有轻微症状？
J Allergy Clin Immunol Pract. 2021 Apr;9(4):1442-1448. doi: 10.1016/j.jaip.2021.01.012. Epub 2021 Jan 21.
2
SARS-CoV-2 leads to a small vessel endotheliitis in the heart.SARS-CoV-2 可导致心脏中小血管内皮炎症。
EBioMedicine. 2021 Jan;63:103182. doi: 10.1016/j.ebiom.2020.103182. Epub 2021 Jan 7.
3
Genetic mechanisms of critical illness in COVID-19.新型冠状病毒肺炎危重症的遗传机制。
Nature. 2021 Mar;591(7848):92-98. doi: 10.1038/s41586-020-03065-y. Epub 2020 Dec 11.
4
Systemic microvascular endothelial dysfunction and disease severity in COVID-19 patients: Evaluation by laser Doppler perfusion monitoring and cytokine/chemokine analysis.新型冠状病毒肺炎患者的系统性微血管内皮功能障碍和疾病严重程度：激光多普勒灌注监测和细胞因子/趋化因子分析评估。
Microvasc Res. 2021 Mar;134:104119. doi: 10.1016/j.mvr.2020.104119. Epub 2020 Dec 3.
5
The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness.ABO 组织血型、内皮细胞激活与危重病急性呼吸窘迫综合征风险。
J Clin Invest. 2021 Jan 4;131(1). doi: 10.1172/JCI139700.