放疗与头颈部癌症患者阻塞性睡眠呼吸暂停的相关性：系统评价和荟萃分析。
Association between radiotherapy and obstructive sleep apnea in head and neck cancer patients: A systematic review and meta-analysis.
机构信息
Faculty of Medicine, Ain Shams University, Cairo, Egypt; Online Research Club (http://onlineresearchclub.org), Nagasaki 852-8523, Japan.
Online Research Club (http://onlineresearchclub.org), Nagasaki 852-8523, Japan; Faculty of Medicine, Port Said University, Port Said, Egypt.
出版信息
Auris Nasus Larynx. 2021 Dec;48(6):1126-1134. doi: 10.1016/j.anl.2021.04.014. Epub 2021 Jun 8.
OBJECTIVE
Our aim was to investigate association between OSA and radiotherapy in head and neck cancer patients.
METHODS
On 9th of September 2018, we have searched 12 electronic databases to retrieve relevant studies. All eligible studies that assessed association between OSA and radiotherapy in head and neck cancer patients were included in our meta-analysis. Quality assessment of included studies was done using the NIH tools for cohort, cross-sectional and case series studies.
RESULTS
Fourteen studies met our study selection criteria, and six studies were eligible for our meta-analysis. There was no significant association between occurrence of OSA and radiotherapy in head and neck cancer patients (Odds ratio 1.54, 95% CI [0.66-3.60]; P = 0.322).
CONCLUSION
These findings point to no significant association between OSA risk and radiotherapy in head and neck cancer patients. We suggest more studies to be conducted to investigate any confounders that may influence the effect of radiotherapy on development of OSA in head and neck cancer patients.
目的
本研究旨在探讨阻塞性睡眠呼吸暂停（OSA）与头颈部癌症患者放疗之间的相关性。
方法
2018 年 9 月 9 日，我们检索了 12 个电子数据库以获取相关研究。所有评估 OSA 与头颈部癌症患者放疗之间相关性的合格研究均纳入我们的荟萃分析。使用 NIH 工具对头颈癌患者队列研究、横断面研究和病例系列研究进行纳入研究的质量评估。
结果
14 项研究符合我们的研究选择标准，其中 6 项研究符合荟萃分析的条件。OSA 的发生与头颈部癌症患者的放疗之间无显著相关性（比值比 1.54，95%CI [0.66-3.60]；P=0.322）。
结论
这些结果表明，OSA 风险与头颈部癌症患者的放疗之间无显著相关性。我们建议进行更多的研究，以调查可能影响放疗对头颈部癌症患者 OSA 发展影响的混杂因素。
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