Madsen S, Thaysen J H, Olgaard K, Heerfordt J, Løkkegaard H
Proc Eur Dial Transplant Assoc. 1977;14:433-41.
In order to investigate the possible reversibility of renal osteodystrophy, eleven necrograft recipients were investigated six years after transplantation, when treatment with prednisone had been withdrawn for 1.5 years. Serum ionised calcium, phosphorus, alkaline phosphatases, PTH, skeletal radiography, Technetium polyphosphate (Tc-PP) bone scintigraphy and radial bone mineral content (BMC) were studied. Normal blood biochemistry, radiography and Tc-PP scintigraphy were found in nine (82%) of the patients, in contrast to the considerably higher frequency of abnormalities ordinarily found in haemodialysis patients. However, the radial BMC was significantly reduced (mean 13.5%) and identical with the BMC value in haemodialysis patients. We conclude that some regression of renal osteodystrophy may take place after a successful kidney transplantation, but that decreased mineralisation of the appendicular skeleton persists. Whether this latter finding is due to long-term steroid treatment or is an indicator of an irreversible component in renal osteodystrophy cannot be stated.
为了研究肾性骨营养不良的可能可逆性，对11例尸体肾移植受者在移植后6年进行了调查，此时已停用泼尼松治疗1.5年。研究了血清离子钙、磷、碱性磷酸酶、甲状旁腺激素、骨骼X线摄影、锝多聚磷酸盐（Tc-PP）骨闪烁显像和桡骨骨矿物质含量（BMC）。9例（82%）患者血液生化、X线摄影和Tc-PP闪烁显像结果正常，这与血液透析患者中通常发现的异常频率高得多形成对比。然而，桡骨BMC显著降低（平均13.5%），与血液透析患者的BMC值相同。我们得出结论，成功肾移植后肾性骨营养不良可能会有一定程度的消退，但附属骨骼的矿化减少仍然存在。后一发现是由于长期使用类固醇治疗，还是肾性骨营养不良中不可逆成分的一个指标，尚无法确定。
