Fries D, Delavelle F, Mathieu D, Jacques L, Renault L
Proc Eur Dial Transplant Assoc. 1977;14:535-40.
In 105 adults with E.Coli urinary tract infections, IgG coated bacteriuria was found in 8/9 with acute pyelonephritis (PN), 17/20 with chronic PN, and in only 2/76 with lower UTI. IgA was present in 66% of PN, but IgA secretory piece in less than 10%. These urinary IgG antibodies were, at least in part, synthesised in the kidney because serum IgG antibodies were detected by indirect immunofluorescence in only half the patients. 06, 018, 022 E.Coli serotypes were the three most frequently found O groups, but their prevalence in PN is not significant. The immunology of urinary tract infection (UTI) is still a subject of little interest in adult nephrology; but antibody production is a well-characterised event in pyelonephritis (PN), the study of which seems to be the best indirect procedure for localising the site of UTI. We have analysed the production of urinary and humoral antibodies, and their correlation with E.Coli serotypes in patients with E.Coli UTI.
在105例患有大肠杆菌尿路感染的成年人中，在8/9例急性肾盂肾炎（PN）、17/20例慢性PN患者中发现了IgG包被菌尿，而在仅2/76例下尿路感染患者中发现。66%的PN患者存在IgA，但分泌片段IgA的患者不到10%。这些尿液IgG抗体至少部分是在肾脏中合成的，因为通过间接免疫荧光法仅在一半的患者中检测到血清IgG抗体。06、018、022大肠杆菌血清型是最常发现的三个O群，但它们在PN中的患病率并不显著。尿路感染（UTI）的免疫学在成人肾脏病学中仍然是一个不太受关注的课题；但抗体产生在肾盂肾炎（PN）中是一个特征明确的事件，对其研究似乎是定位UTI部位的最佳间接方法。我们分析了大肠杆菌UTI患者尿液和体液抗体的产生及其与大肠杆菌血清型的相关性。
