Sølling K, Mogensen C E
Proc Eur Dial Transplant Assoc. 1977;14:543-9.
Amino acids and derivatives were injected intravenously in normal man and the effect on the urinary excretion of albumin, free light chains and beta-2-microglobulin determined. From the results we hypothesise that the initial event in normal protein reabsorption is binding between a free positive amino- or guanidino-group of the protein molecule and a negative site on the tubular cell surface. This initial event in the reabsorption process is impeded by molecules containing similar charged groups (arginine, ornithine, lysine, EACA and Cyclocaprone). Using high doses of lysine, complete or near-complete inhibition of tubular protein reabsorption is obtained. The glomerular filtration rate in preliminary experiments is found to be of the order of 300 microgram/min for albumin.
在正常人体内静脉注射氨基酸及其衍生物，并测定其对白蛋白、游离轻链和β2微球蛋白尿排泄的影响。根据实验结果，我们推测正常蛋白质重吸收的起始事件是蛋白质分子游离的正性氨基或胍基与肾小管细胞表面的负性位点之间的结合。重吸收过程中的这一起始事件会受到含有相似电荷基团的分子（精氨酸、鸟氨酸、赖氨酸、6-氨基己酸和环卡普明）的阻碍。使用高剂量的赖氨酸，可实现肾小管蛋白质重吸收的完全或近乎完全抑制。在初步实验中，发现白蛋白的肾小球滤过率约为300微克/分钟。
