Neurology, Spinal Cord Injury Center, Balgrist University Hospital, University of Zürich, Switzerland.
Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Italy.
Neurorehabil Neural Repair. 2021 Aug;35(8):659-662. doi: 10.1177/15459683211023191. Epub 2021 Jun 11.
. The prediction of functional outcomes after spinal cord injury (SCI) is essential to plan the rehabilitation phase and the social reintegration. Recently, 2 models to predict independent and reliable bowel management 1 year after traumatic SCI have been derived and validated in 2 cohorts of patients included in the European Multicenter Study about Spinal Cord Injury (EMSCI). . We aimed to validate 2 prediction models for bowel outcome after traumatic SCI in a patient sample external to EMSCI. . The simplified model (based on a single predictor, the International Standards for Neurological Classification of Spinal Cord Injury [ISNCSCI] total motor score) and the full model (based on 2 predictors, the ISNCSCI total motor score and item 3a of the Spinal Cord Independence Measure) were applied to the retrospectively collected data of 111 patients with traumatic SCI. . The simplified and the full models showed excellent discrimination with an area under the receiver operating characteristic curve of .939 (95% confidence interval (CI) .87-1.00) and .922 (95% CI 0.85-.99), respectively. Both models displayed similar results for sensitivity and negative predictive values; however, the simplified model showed higher values for specificity, positive predictive values, and accuracy. The calibration analysis showed a partial overlap between predicted probabilities and observed proportion, with better and acceptable calibration for the simplified model. . Using an independent sample, our study demonstrates the validity of a simple model to predict independent and reliable bowel management 1 year after traumatic SCI.
. 脊髓损伤(SCI)后功能预后的预测对于规划康复阶段和社会重新融入至关重要。最近,已经在包括在欧洲脊髓损伤多中心研究(EMSCI)中的两个患者队列中得出并验证了 2 个预测创伤性 SCI 后独立且可靠的肠道管理 1 年的模型。. 我们旨在验证 2 个用于创伤性 SCI 后肠道结果的预测模型在 EMSCI 之外的患者样本中的有效性。. 简化模型(基于单个预测因子,即脊髓损伤神经功能分类国际标准 [ISNCSCI] 总运动评分)和全模型(基于 2 个预测因子,即 ISNCSCI 总运动评分和脊髓独立性测量的项目 3a)被应用于 111 例创伤性 SCI 患者的回顾性数据。. 简化模型和全模型均具有出色的区分度,其受试者工作特征曲线下面积分别为.939(95%置信区间 [CI].87-1.00)和.922(95% CI 0.85-.99)。两个模型的敏感性和阴性预测值均相似;然而,简化模型的特异性、阳性预测值和准确性更高。校准分析显示预测概率和观察到的比例之间存在部分重叠,简化模型的校准更好且可接受。. 使用独立样本,我们的研究证明了一种简单模型预测创伤性 SCI 后 1 年独立且可靠的肠道管理的有效性。