Jones R C, Stone G M, Hinds L A, Setchell B P
Department of Biological Sciences, University of Newcastle, NSW, Australia.
J Reprod Fertil. 1988 Jul;83(2):779-83. doi: 10.1530/jrf.0.0830779.
The activity of 5 alpha-reductase was much higher in the caput and corpus epididymidis than in the cauda epididymidis. Orchidectomy caused a reduction in 5 alpha-reductase activity in the caput and corpus epididymidis, and regression of the epithelium and reduction in mass of all regions of the epididymis. Subsequent testosterone therapy caused a substantial increase in amount of epithelium and overall mass of the cauda epididymidis but showed little or no increase in any of the responses measured in the caput and corpus epididymidis. We concluded that the caput and corpus epididymidis of the tammar respond to factors other than testosterone, probably some constituent in the luminal fluid, and therefore are homologous with the initial segments of the epididymis in eutherians.
5α-还原酶的活性在附睾头和附睾体中比在附睾尾中高得多。睾丸切除导致附睾头和附睾体中5α-还原酶活性降低，附睾上皮退化以及附睾所有区域的质量减轻。随后的睾酮治疗使附睾尾的上皮数量和总体质量大幅增加，但在附睾头和附睾体中所测量的任何反应几乎没有增加或没有增加。我们得出结论，袋貂的附睾头和附睾体对睾酮以外的因素有反应，可能是管腔液中的某些成分，因此与真兽类附睾的起始段同源。
