Liu Xiaoyang, Wu Yuxuan, Zhao Xinchen, Wang Zhengke
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Carbohydr Polym. 2021 Sep 1;267:118179. doi: 10.1016/j.carbpol.2021.118179. Epub 2021 May 8.
Organic-inorganic hybrid materials like bone, shells, and teeth can be found in nature, which are usually composed of biomacromolecules and nanoscale inorganic ingredients. Synergy of organic-inorganic components in hybrid materials render them outstanding and versatile performance. Chitosan is commonly used organic materials in bionic hybrid materials since its bioactive properties and could be controllable tailored by various means to meet complex conditions in different applications. Among these fabrication means, hybridization was favored for its convenience and efficiency. This review discusses three kinds of chitosan-based hybrid materials: hybridized with hydroxyapatite, calcium carbonate, and clay respectively, which are the representative of phosphate, carbonate, and hydrous aluminosilicates. Here, we reported the latest developments of the preparation methods, composition, structure and applications of these bioactive hybrid materials, especially in the biomedical field. Despite the great progress was made in bioactive organic-inorganic hybrid materials based on chitosan, some challenges and specific directions are still proposed for future development in this review.
诸如骨骼、贝壳和牙齿之类的有机-无机杂化材料在自然界中随处可见，它们通常由生物大分子和纳米级无机成分组成。杂化材料中有机-无机成分的协同作用使其具有出色且多样的性能。壳聚糖因其生物活性特性，是仿生杂化材料中常用的有机材料，并且可以通过各种方法进行可控定制，以满足不同应用中的复杂条件。在这些制备方法中，杂化因其便利性和高效性而受到青睐。本综述讨论了三种基于壳聚糖的杂化材料：分别与羟基磷灰石、碳酸钙和粘土杂化，它们分别是磷酸盐、碳酸盐和含水铝硅酸盐的代表。在此，我们报道了这些生物活性杂化材料在制备方法、组成、结构和应用方面的最新进展，尤其是在生物医学领域。尽管基于壳聚糖的生物活性有机-无机杂化材料取得了巨大进展，但本综述仍针对未来发展提出了一些挑战和具体方向。
