Duraisamy Revathi, Ganapathy Dhanraj, Shanmugam Rajeshkumar, Devaraj Ezhilarasan, Shenoy Amrutha
Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus. 2024 Jan 31;16(1):e53339. doi: 10.7759/cureus.53339. eCollection 2024 Jan.
The objective of this study was to evaluate the antimicrobial potential of nanocomposites containing vitamin K2, hydroxyapatite nanoparticles (nHAP), and chitosan (Chito)-coated dental implants against clinically relevant microbial strains.
Four test compounds were prepared: vitamin K2 + nHAP, K2 + Chito + nHAP, vitamin K2, and vitamin K2 + Chito. Agar well diffusion test was conducted to assess the antimicrobial activity of these compounds against and Results: The vitamin K2 + nHAP nanocomposite exhibited antimicrobial activity against all tested microorganisms, with showing the highest sensitivity (25 mm zone of inhibition at 100 µL concentration). The K2 + Chito + nHAP nanocomposite demonstrated potent antimicrobial activity with displaying the highest sensitivity (28 mm zone of inhibition at 100 µL concentration). Pure vitamin K2 showed limited antimicrobial activity, vitamin K2 combined with chitosan exhibited significant susceptibility to , resulting in a substantial inhibition zone of 24 mm diameter at a concentration of 100 µL.
The synergistic effects of vitamin K2 with nHAP and chitosan highlight the potential of these nanocomposites for biomedical applications. These findings contribute to the development of effective nanocomposites to address antimicrobial resistance and improve infection control in various biomedical fields.
本研究的目的是评估含有维生素K2、羟基磷灰石纳米颗粒（nHAP）和壳聚糖（Chito）涂层的牙科植入物的纳米复合材料对临床相关微生物菌株的抗菌潜力。
制备了四种测试化合物：维生素K2 + nHAP、K2 + Chito + nHAP、维生素K2和维生素K2 + Chito。进行琼脂扩散试验以评估这些化合物对[具体微生物名称1]和[具体微生物名称2]的抗菌活性。结果：维生素K2 + nHAP纳米复合材料对所有测试微生物均表现出抗菌活性，其中[具体微生物名称1]显示出最高敏感性（在100μL浓度下抑菌圈为25mm）。K2 + Chito + nHAP纳米复合材料表现出强大的抗菌活性，[具体微生物名称2]显示出最高敏感性（在100μL浓度下抑菌圈为28mm）。纯维生素K2显示出有限的抗菌活性，维生素K2与壳聚糖组合对[具体微生物名称2]表现出显著敏感性，在100μL浓度下产生直径为24mm的显著抑菌圈。
维生素K2与nHAP和壳聚糖的协同作用突出了这些纳米复合材料在生物医学应用中的潜力。这些发现有助于开发有效的纳米复合材料，以应对抗菌耐药性并改善各种生物医学领域的感染控制。
