甲状腺乳头状癌中 TREM-1 过表达的预后价值及潜在分子机制分析 生物信息学方法。
Analysis of the Prognostic Value and Potential Molecular Mechanisms of TREM-1 Overexpression in Papillary Thyroid Cancer Bioinformatics Methods.
机构信息
Department of Vascular and Thyroid Surgery, The First Hospital, China Medical University, Shenyang, China.
出版信息
Front Endocrinol (Lausanne). 2021 May 27;12:646793. doi: 10.3389/fendo.2021.646793. eCollection 2021.
BACKGROUND
Triggering receptor expressed on myeloid cells-1 (TREM-1) has been reported as a biomarker in many cancers. However, the biological function of TREM-1 in papillary thyroid carcinoma (PTC) remains unknown.
METHODS
We obtained TREM-1 expression data from The Cancer Genome Atlas (TCGA) database. Enrichment analysis of coexpressed genes and methylation analysis were performed LinkedOmics. The correlations between TREM-1 and immune infiltrates were investigated ESTIMATE, TIMER and TISIDB. We analyzed the association of TREM-1 expression with pan-cancer overall survival Gene Expression Profiling Interactive Analysis (GEPIA).
RESULTS
has lower methylation levels and higher expression levels in PTC tissues compared to normal tissues. TREM-1 expression is significantly associated with poor prognosis, advanced T classification, advanced N classification, and an increased incidence of and mutations. Genes coexpressed with primarily participate in immune-related pathways. TREM-1 expression is positively correlated with immune infiltration, tumor progression and poor overall survival across cancers.
CONCLUSIONS
TREM-1 is a good prognostic and diagnostic biomarker in PTC. TREM-1 may promote thyroid cancer progression through immune-related pathways. Methylation may act as an upstream regulator of TREM-1 expression and biological function. Additionally, TREM-1 has broad prognostic value in a pan-cancer cohort.
背景
髓样细胞表达的触发受体-1（TREM-1）已被报道为许多癌症的生物标志物。然而，TREM-1 在甲状腺乳头状癌（PTC）中的生物学功能尚不清楚。
方法
我们从癌症基因组图谱（TCGA）数据库中获得了 TREM-1 表达数据。使用 LinkedOmics 进行共表达基因富集分析和甲基化分析。通过 ESTIMATE、TIMER 和 TISIDB 分析 TREM-1 与免疫浸润的相关性。我们通过基因表达谱交互分析（GEPIA）分析 TREM-1 表达与泛癌总生存期的关联。
结果
与正常组织相比，PTC 组织中的甲基化水平较低，表达水平较高。TREM-1 表达与不良预后、晚期 T 分类、晚期 N 分类以及 和 突变发生率增加显著相关。与 共表达的基因主要参与免疫相关途径。TREM-1 表达与癌症中的免疫浸润、肿瘤进展和不良总生存期呈正相关。
结论
TREM-1 是 PTC 的良好预后和诊断生物标志物。TREM-1 可能通过免疫相关途径促进甲状腺癌的进展。甲基化可能作为 TREM-1 表达和生物学功能的上游调节剂。此外，TREM-1 在泛癌队列中具有广泛的预后价值。
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