Division of Tumour Biology & Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, Netherlands.
Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands.
Nat Rev Immunol. 2020 Aug;20(8):483-497. doi: 10.1038/s41577-019-0271-z. Epub 2020 Feb 5.
Metastatic disease is responsible for approximately 90% of cancer deaths. For successful dissemination and metastasis, cancer cells must evade detection and destruction by the immune system. This process is enabled by factors secreted by the primary tumour that shape both the intratumoural microenvironment and the systemic immune landscape. Here, we review the evidence of aberrant immune cell crosstalk in metastasis formation and the role that primary tumours play in hijacking these interactions in order to enhance their metastatic potential. Moreover, we highlight the intriguing parallels between the inflammatory pathways underlying inflammatory disorders and cancer progression.
转移性疾病约占癌症死亡人数的 90%。为了成功扩散和转移，癌细胞必须逃避免疫系统的检测和破坏。这一过程是由原发性肿瘤分泌的因子所驱动的，这些因子不仅塑造了肿瘤内的微环境，还塑造了全身的免疫景观。在这里，我们回顾了在转移形成过程中异常免疫细胞串扰的证据，以及原发性肿瘤在劫持这些相互作用以增强其转移潜力方面所起的作用。此外，我们还强调了炎症性疾病和癌症进展背后的炎症途径之间存在的有趣相似之处。
