Medicine/Infectious Diseases Division, Henry Ford Hospital/Wayne State University, Detroit, MI, USA.
Medical School, Michigan State University, Detroit, MI, USA.
AIDS Care. 2022 Mar;34(3):404-407. doi: 10.1080/09540121.2021.1939258. Epub 2021 Jun 14.
Daily adherence to lifelong antiretroviral therapy (ART) is required to achieve long term treatment success. However, patient preferences for ART tablet size have not been well studied. Our study assessed factors associated with the ease of swallowing (EoS) and tolerability of two placebo tablets representing and matching B/F/TAF (BPT) and DTG/ABC/3TC (DPT). Fifty ART-naïve patients were randomized into a two-period cross-over study. Likert scale (1-5) questionnaires were administered to assess patient factors influencing the ease of swallowing, adherence, home medications, medication preferences and perceptions. Comparisons were done using Student -tests and ordinal regression. Participants were 64% female, 61% white, mean age 43 years, and taking a mean (median) of 4(1) pills/day. BPT was reported to be easier than DPT with ease of swallowability 1.76 vs. 2.42 (< 0.001) (1 = very easy). DPT tablet was correctly perceived as larger than BPT (< 0.001); with both tablets perceived as smaller than actual size (< 0.001). EoS of either tablet was positively associated with the EoS of the largest home tablet medication ( = 0.021, = 0.03). Patient's perceptions of EoS can affect their medication adherence, especially in HIV, and should be considered in treatment regimens.
患者需要每天坚持使用抗逆转录病毒疗法（ART）才能实现长期治疗成功。然而，患者对 ART 片剂大小的偏好尚未得到充分研究。我们的研究评估了与两种代表并匹配 B/F/TAF（BPT）和 DTG/ABC/3TC（DPT）的安慰剂片剂的吞咽舒适度（EoS）和耐受性相关的因素。50 名初治的 ART 患者被随机分为两期交叉研究。采用李克特量表（1-5）问卷评估影响吞咽舒适度、依从性、家庭用药、药物偏好和认知的患者因素。采用学生 t 检验和有序回归进行比较。参与者中女性占 64%，白人占 61%，平均年龄 43 岁，平均（中位数）每天服用 4（1）片。BPT 的吞咽舒适度报告为 1.76，明显优于 DPT 的 2.42（<0.001）（1=非常容易）。DPT 片剂被正确认为比 BPT 更大（<0.001）；两种片剂均被认为比实际尺寸小（<0.001）。任何一种片剂的 EoS 与最大的家庭用药片剂的 EoS 呈正相关（ =0.021， =0.03）。患者对 EoS 的认知会影响他们的用药依从性，尤其是在 HIV 中，应在治疗方案中考虑到这一点。
