Dohopolski Michael, Gottumukkala Sujana, Gomez Daniel, Iyengar Puneeth
Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas, USA.
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Cold Spring Harb Perspect Med. 2021 Oct 1;11(10):a037713. doi: 10.1101/cshperspect.a037713.
The management of non-small-cell lung cancer (NSCLC) varies according to stage. Surgical resection is reserved for operable patients with early-stage NSCLC, while high-dose target radiation-stereotactic body radiation therapy (SBRT)-is reserved for patients whose comorbidities prohibit them from a major surgical procedure. The treatment of locally advanced NSCLC (LA-NSCLC) is stratified according to resectability. Those with resectable disease may require additional treatments such as chemotherapy and radiation, while patients with unresectable disease will require definitive chemoradiation therapy with adjuvant durvalumab. Patients with limited metastatic disease benefit from the combination of SBRT and systemic therapy.
非小细胞肺癌(NSCLC)的治疗方案因分期而异。手术切除适用于早期可手术的NSCLC患者,而高剂量靶向放疗——立体定向体部放疗(SBRT)——则适用于因合并症而无法进行大型外科手术的患者。局部晚期NSCLC(LA-NSCLC)的治疗根据可切除性进行分层。可切除疾病的患者可能需要额外的治疗,如化疗和放疗,而不可切除疾病的患者则需要使用辅助度伐鲁单抗进行确定性放化疗。转移性疾病有限的患者可从SBRT与全身治疗的联合中获益。