Roach T I, Wakelin D, Else K J, Bundy D A
Department of Zoology, University of Nottingham, UK.
Parasite Immunol. 1988 May;10(3):279-91. doi: 10.1111/j.1365-3024.1988.tb00221.x.
Cross-reactivity was demonstrated between circulating antibodies from Trichuris trichiura-infected humans and T. muris-infected mice for heterologous antigen preparations. Mouse immune sera raised against excretory/secretory (E/S) products and anterior end homogenate from adult T. muris showed marked affinity for T. trichiura adult homogenate in ELISA, and 35S-methionine-labelled adult T. muris E/S products were precipitated by T. trichiura infection sera. Monoclonal antibodies recognizing a 48 kD Trichinella spiralis muscle larval beta-stichocyte granule antigen also showed avidity for T. trichiura adult homogenate in ELISA, as did serum from mice with patent T. muris worm burdens. This cross-reactivity is thought to result from shared stichocyte antigens and the relevance of this observation is discussed.
已证明来自感染毛首鞭形线虫的人类和感染小鼠鞭虫的小鼠的循环抗体之间，对于异源抗体制剂存在交叉反应性。用成年小鼠鞭虫的排泄/分泌（E/S）产物和前端匀浆免疫的小鼠血清，在ELISA中对毛首鞭形线虫成虫匀浆表现出显著亲和力，且感染毛首鞭形线虫的血清可沉淀35S-甲硫氨酸标记的成年小鼠鞭虫E/S产物。识别旋毛虫肌肉幼虫β-刺细胞颗粒抗原的单克隆抗体，在ELISA中也对毛首鞭形线虫成虫匀浆表现出亲和力，感染小鼠鞭虫成虫的小鼠血清也如此。这种交叉反应性被认为是由共同的刺细胞抗原导致的，并讨论了该观察结果的相关性。
