• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

盐酸兰地洛尔对组胺诱导性休克模型血流动力学的影响。

Effect of Landiolol Hydrochloride on Hemodynamics in a Histamine-Induced Shock Model.

机构信息

Department of Cardiology, Tokyo Medical University, 6-7-1, Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Clinical Development Planning, Ono Pharmaceutical Co., Ltd, Osaka, Japan.

出版信息

Drugs R D. 2021 Sep;21(3):321-329. doi: 10.1007/s40268-021-00354-3. Epub 2021 Jun 14.

DOI:10.1007/s40268-021-00354-3
PMID:34128200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8363724/
Abstract

BACKGROUND AND OBJECTIVE

Anaphylactic shock is a serious adverse drug reaction that can occur in response to contrast media used during coronary computed tomography angiography. The imaging quality of coronary computed tomography angiography is improved by β-blockers, which decrease heart rate. In this study, we sought to analyze anaphylactic shock treatment in patients receiving short-acting β1-blockers.

METHODS

We examined the influence of epinephrine and glucagon on hemodynamics during β-blocker treatment, using a dog histamine shock model; the β1-blocker landiolol hydrochloride was used. The effects of these drugs were assessed by recording changes relative to established baselines.

RESULTS

Histamine and landiolol decreased mean blood pressure. Histamine exerted no apparent effect on heart rate, whereas landiolol decreased heart rate. Further, landiolol reduced histamine-mediated increases in the force of cardiac contraction. Increasing the doses of epinephrine and glucagon ameliorated anaphylactic shock-induced deterioration in hemodynamic parameters in subjects receiving landiolol.

CONCLUSIONS

In patients receiving landiolol for coronary computed tomography angiography, deterioration in hemodynamic parameters due to anaphylactic shock can be mitigated by increasing the doses of epinephrine and glucagon. Clinicians should thus prepare appropriate amounts of epinephrine and glucagon prior to coronary computed tomography angiography.

摘要

背景和目的

过敏反应性休克是一种严重的药物不良反应，可发生于冠状动脉计算机断层扫描血管造影术（CCTA）中使用的造影剂。β受体阻滞剂可降低心率，从而提高 CCTA 的成像质量。本研究旨在分析接受短效β1受体阻滞剂治疗的患者发生过敏反应性休克的治疗方法。

方法

我们使用犬组氨酸休克模型，检查了肾上腺素和胰高血糖素对β受体阻滞剂治疗期间血流动力学的影响，使用盐酸兰地洛尔。通过记录相对于既定基线的变化来评估这些药物的效果。

结果

组氨酸和兰地洛尔降低了平均血压。组氨酸对心率没有明显影响，而兰地洛尔降低了心率。此外，兰地洛尔降低了组氨酸介导的心肌收缩力增加。增加肾上腺素和胰高血糖素的剂量可改善接受兰地洛尔治疗的患者的过敏反应性休克引起的血流动力学参数恶化。

结论

在接受兰地洛尔进行 CCTA 的患者中，过敏反应性休克导致的血流动力学参数恶化可通过增加肾上腺素和胰高血糖素的剂量来缓解。因此，临床医生在进行 CCTA 前应准备适量的肾上腺素和胰高血糖素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/bec3be6e92cc/40268_2021_354_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/20fe2ec1f27a/40268_2021_354_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/e5934b2d560e/40268_2021_354_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/c7ee65ee8e64/40268_2021_354_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/0e2844e4f89d/40268_2021_354_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/2b8a77a12dc7/40268_2021_354_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/a12f6b2ccab0/40268_2021_354_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/3dc8c905a417/40268_2021_354_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/bec3be6e92cc/40268_2021_354_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/20fe2ec1f27a/40268_2021_354_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/e5934b2d560e/40268_2021_354_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/c7ee65ee8e64/40268_2021_354_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/0e2844e4f89d/40268_2021_354_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/2b8a77a12dc7/40268_2021_354_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/a12f6b2ccab0/40268_2021_354_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/3dc8c905a417/40268_2021_354_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6499/8363724/bec3be6e92cc/40268_2021_354_Fig8_HTML.jpg

相似文献

1
Effect of Landiolol Hydrochloride on Hemodynamics in a Histamine-Induced Shock Model.盐酸兰地洛尔对组胺诱导性休克模型血流动力学的影响。
Drugs R D. 2021 Sep;21(3):321-329. doi: 10.1007/s40268-021-00354-3. Epub 2021 Jun 14.
2
A randomized, double-blind, placebo-controlled, phase III study of the short-acting β1-adrenergic receptor blocker landiolol hydrochloride for coronary computed tomography angiography in Japanese patients with suspected ischemic cardiac disease.一项针对疑似缺血性心脏病日本患者的冠状动脉计算机断层扫描血管造影中短效β1-肾上腺素能受体阻滞剂盐酸兰地洛尔的随机、双盲、安慰剂对照、III 期研究。
Clin Drug Investig. 2014 Jan;34(1):53-62. doi: 10.1007/s40261-013-0149-y.
3
Safety and efficacy of a bolus injection of landiolol hydrochloride as a premedication for multidetector-row computed tomography coronary angiography.盐酸兰地洛尔注射液负荷量给药作为多层螺旋 CT 冠状动脉造影检查前用药的安全性和有效性。
Circ J. 2013;77(1):146-52. doi: 10.1253/circj.cj-12-0663. Epub 2012 Oct 3.
4
A multicenter, open-label study of an intravenous short-acting β1-adrenergic receptor antagonist landiolol hydrochloride for coronary computed tomography angiography by 16-slice multi-detector computed tomography in Japanese patients with suspected ischemic cardiac disease.一项关于静脉注射短效β1肾上腺素能受体拮抗剂盐酸兰地洛尔用于日本疑似缺血性心脏病患者16层多探测器计算机断层扫描冠状动脉计算机断层血管造影的多中心、开放标签研究。
Drugs R D. 2014 Sep;14(3):185-94. doi: 10.1007/s40268-014-0056-6.
5
Efficacy of landiolol in attenuating hemodynamic responses to local epinephrine infiltration in patients undergoing vaginal total hysterectomy.兰地洛尔对接受阴道全子宫切除术患者局部肾上腺素浸润所致血流动力学反应的衰减作用。
J Anesth. 2005;19(1):17-20. doi: 10.1007/s00540-004-0281-1.
6
Acute hemodynamic effects of landiolol, an ultra-short-acting beta-blocker, in patients with acute coronary syndrome: preliminary study.急性冠状动脉综合征患者应用超短效β受体阻滞剂拉替洛尔的急性血液动力学效应：初步研究。
J Cardiol. 2012 Oct;60(4):252-6. doi: 10.1016/j.jjcc.2012.06.010. Epub 2012 Jul 25.
7
[Effects of landiolol hydrochloride on cardiohemodynamics in patients who underwent coronary artery bypass grafting].盐酸兰地洛尔对冠状动脉旁路移植术患者心脏血流动力学的影响
Masui. 2005 Apr;54(4):402-7.
8
Dose-finding study of landiolol hydrochloride: a short-acting β1-blocker for controlling heart rate during coronary computed-tomography angiography in Japan.盐酸兰地洛尔的剂量探索研究：一种用于控制日本冠状动脉计算机断层扫描血管造影时心率的短效β1-受体阻滞剂。
Adv Ther. 2013 Sep;30(9):803-18. doi: 10.1007/s12325-013-0053-0. Epub 2013 Sep 24.
9
A randomized, double-blind, placebo-controlled, phase II dose-finding study of the short acting β1-blocker, landiolol hydrochloride, in patients with suspected ischemic cardiac disease.一项随机、双盲、安慰剂对照的 II 期剂量探索研究，评估短期作用的β1-受体阻滞剂盐酸兰地洛尔在疑似缺血性心脏病患者中的疗效。
Int J Cardiovasc Imaging. 2013 Jun;29 Suppl 1(Suppl 1):7-20. doi: 10.1007/s10554-013-0253-3. Epub 2013 Jun 20.
10
Modifications of the hemodynamic consequences of theophylline intoxication with landiolol in halothane-anesthetized dogs.在氟烷麻醉的犬中，用兰地洛尔改善氨茶碱中毒的血流动力学后果。
Can J Anaesth. 2000 Mar;47(3):265-72. doi: 10.1007/BF03018925.

本文引用的文献

1
2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC).2017年欧洲心脏病学会（ESC）ST段抬高型急性心肌梗死患者管理指南：欧洲心脏病学会（ESC）ST段抬高型急性心肌梗死患者管理工作组
Eur Heart J. 2018 Jan 7;39(2):119-177. doi: 10.1093/eurheartj/ehx393.
2
2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.2014年美国心脏协会/美国心脏病学会非ST段抬高型急性冠状动脉综合征患者管理指南：美国心脏病学会/美国心脏协会实践指南工作组报告
Circulation. 2014 Dec 23;130(25):e344-426. doi: 10.1161/CIR.0000000000000134. Epub 2014 Sep 23.
3
A multicenter, open-label study of an intravenous short-acting β1-adrenergic receptor antagonist landiolol hydrochloride for coronary computed tomography angiography by 16-slice multi-detector computed tomography in Japanese patients with suspected ischemic cardiac disease.一项关于静脉注射短效β1肾上腺素能受体拮抗剂盐酸兰地洛尔用于日本疑似缺血性心脏病患者16层多探测器计算机断层扫描冠状动脉计算机断层血管造影的多中心、开放标签研究。
Drugs R D. 2014 Sep;14(3):185-94. doi: 10.1007/s40268-014-0056-6.
4
A randomized, double-blind, placebo-controlled, phase III study of the short-acting β1-adrenergic receptor blocker landiolol hydrochloride for coronary computed tomography angiography in Japanese patients with suspected ischemic cardiac disease.一项针对疑似缺血性心脏病日本患者的冠状动脉计算机断层扫描血管造影中短效β1-肾上腺素能受体阻滞剂盐酸兰地洛尔的随机、双盲、安慰剂对照、III 期研究。
Clin Drug Investig. 2014 Jan;34(1):53-62. doi: 10.1007/s40261-013-0149-y.
5
Dose-finding study of landiolol hydrochloride: a short-acting β1-blocker for controlling heart rate during coronary computed-tomography angiography in Japan.盐酸兰地洛尔的剂量探索研究：一种用于控制日本冠状动脉计算机断层扫描血管造影时心率的短效β1-受体阻滞剂。
Adv Ther. 2013 Sep;30(9):803-18. doi: 10.1007/s12325-013-0053-0. Epub 2013 Sep 24.
6
A randomized, double-blind, placebo-controlled, phase II dose-finding study of the short acting β1-blocker, landiolol hydrochloride, in patients with suspected ischemic cardiac disease.一项随机、双盲、安慰剂对照的 II 期剂量探索研究，评估短期作用的β1-受体阻滞剂盐酸兰地洛尔在疑似缺血性心脏病患者中的疗效。
Int J Cardiovasc Imaging. 2013 Jun;29 Suppl 1(Suppl 1):7-20. doi: 10.1007/s10554-013-0253-3. Epub 2013 Jun 20.
7
World allergy organization guidelines for the assessment and management of anaphylaxis.世界过敏组织过敏反应评估和管理指南。
World Allergy Organ J. 2011 Feb;4(2):13-37. doi: 10.1097/WOX.0b013e318211496c. Epub 2011 Feb 23.
8
ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC).欧洲心脏病学会（ESC）非持续性ST段抬高型急性冠状动脉综合征患者管理指南：欧洲心脏病学会（ESC）非持续性ST段抬高型急性冠状动脉综合征（ACS）管理工作组。
Eur Heart J. 2011 Dec;32(23):2999-3054. doi: 10.1093/eurheartj/ehr236. Epub 2011 Aug 26.
9
ACCF/ACR/AHA/NASCI/SAIP/SCAI/SCCT 2010 expert consensus document on coronary computed tomographic angiography: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents.ACCF/ACR/AHA/NASCI/SAIP/SCAI/SCCT 2010年冠状动脉计算机断层扫描血管造影专家共识文件：美国心脏病学基金会专家共识文件特别工作组报告
Circulation. 2010 Jun 8;121(22):2509-43. doi: 10.1161/CIR.0b013e3181d4b618. Epub 2010 May 17.
10
Diagnostic performance of coronary angiography by 64-row CT.64排CT冠状动脉造影的诊断性能
N Engl J Med. 2008 Nov 27;359(22):2324-36. doi: 10.1056/NEJMoa0806576.