Intensive Care Unit, Hospital Universitario De Canarias. Ofra, Santa Cruz de Tenerife, Spain.
Intensive Care Unit, Hospital Universitario Nuestra Señora De Candelaria, Santa Cruz de Tenerife, Spain.
Expert Rev Mol Diagn. 2021 Aug;21(8):837-844. doi: 10.1080/14737159.2021.1941880. Epub 2021 Jun 27.
There are no data on circulating concentrations of sFas (proapoptotic protein of extrinsic pathway) and Bcl2 (antiapoptotic protein of intrinsic pathway) in COVID-19 patients. Thus, our objective study was to determine whether an association exists between serum concentrations of sFas and Bcl2 and COVID-19 patient mortality. This observational and prospective study of COVID-19 patients was performed in eight Intensive Care Units (ICU) from Canary Islands (Spain). Serum levels of sFas and Bcl2 at ICU admission were determined. Mortality at 30 days was the end-point study. Surviving patients ( = 42) compared to non-surviving ( = 11) had lower APACHE-II ( < 0.001), lower SOFA ( = 0.004), lower serum sFas levels ( = 0.001) and higher serum Bcl2 levels ( < 0.001). Logistic regression showed an association between high serum sFas levels and mortality after controlling for APACHE-II (OR = 1.004; 95% CI = 1.101-1.007; = 0.01) or SOFA (OR = 1.003; 95% CI = 1.101-1.106; = 0.004), and between low serum Bcl2 levels and mortality after controlling for APACHE-II (OR = 0.927; 95% CI = 0.873-0.984; = 0.01) or SOFA (OR = 0.949; 95% CI = 0.913-0.987; = 0.01). Thus, to the best of our knowledge, this is the first study reporting blood levels of sFas and Bcl2 in COVID-19 patients and its association with mortality.
目前尚无关于 COVID-19 患者循环中 sFas（外源性途径的促凋亡蛋白）和 Bcl2（内源性途径的抗凋亡蛋白）浓度的数据。因此，我们的目的是确定血清 sFas 和 Bcl2 浓度与 COVID-19 患者死亡率之间是否存在关联。这项针对 COVID-19 患者的观察性和前瞻性研究在西班牙加那利群岛的 8 个重症监护病房（ICU）进行。在 ICU 入院时测定血清 sFas 和 Bcl2 水平。30 天的死亡率为终点研究。与存活患者（=42）相比，非存活患者（=11）的 APACHE-II 评分较低（<0.001），SOFA 评分较低（=0.004），血清 sFas 水平较低（=0.001），血清 Bcl2 水平较高（<0.001）。多变量逻辑回归显示，在校正 APACHE-II（比值比 [OR] = 1.004；95%置信区间 [CI] = 1.101-1.007；=0.01）或 SOFA（OR = 1.003；95%CI = 1.101-1.106；=0.004）后，高血清 sFas 水平与死亡率相关，在校正 APACHE-II（OR = 0.927；95%CI = 0.873-0.984；=0.01）或 SOFA（OR = 0.949；95%CI = 0.913-0.987；=0.01）后，低血清 Bcl2 水平与死亡率相关。因此，据我们所知，这是第一项报告 COVID-19 患者血清 sFas 和 Bcl2 水平及其与死亡率相关性的研究。
