Dr. Phillip Frost Department of Dermatology and Miami Itch Center, University of Miami, Miami, FL, USA.
The Kimberly and Eric J. Waldman Department of Dermatology at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Arch Dermatol Res. 2022 Jul;314(5):405-415. doi: 10.1007/s00403-021-02255-6. Epub 2021 Jun 15.
Chronic pruritus carries a significant burden of disease and is associated with a negative impact on quality of life. African Americans are disproportionately burdened by chronic pruritic disorders, including but not limited to atopic dermatitis, prurigo nodularis, inflammatory scalp dermatoses, pathologic scarring, and HIV-related dermatoses. Racial differences in skin structure and function may contribute to the pathogenesis of itch in African Americans. Itch perception and response to treatment in African Americans remain understudied and not well understood. As such, there is a large unmet need with regard to the knowledge and management of pruritus in African Americans. This review highlights notable differences in the epidemiology, pathophysiology, genetic predisposition, clinical presentation, and response to treatment for select pruritic skin conditions. By addressing itch as an unmet need in African Americans, we hope to improve patient outcomes and lessen disparities in dermatologic care.
慢性瘙痒带来了巨大的疾病负担，并对生活质量产生负面影响。非裔美国人受到慢性瘙痒性疾病的影响不成比例，包括但不限于特应性皮炎、结节性痒疹、炎症性头皮皮肤病、病理性瘢痕和与 HIV 相关的皮肤病。皮肤结构和功能的种族差异可能导致非裔美国人的瘙痒发病机制。非裔美国人的瘙痒感知和对治疗的反应仍研究不足，也不被充分了解。因此，在非裔美国人的瘙痒症的知识和管理方面存在巨大的未满足的需求。这篇综述强调了一些特定瘙痒性皮肤疾病在流行病学、病理生理学、遗传易感性、临床表现和治疗反应方面的显著差异。通过将瘙痒作为非裔美国人的未满足需求来解决，我们希望改善患者的预后并减少皮肤科护理中的差异。
