Department of Public Health Sciences, Division of Prevention Science and Community Health, University of Miami Miller School of Medicine, 1120NW 14th St. Office 1005, Miami, FL, 33136, USA.
Department of Medicine, Center for AIDS Prevention Studies, Francisco Center School of Medicine, University of San, San Francisco, CA, USA.
AIDS Behav. 2021 Sep;25(9):2699-2711. doi: 10.1007/s10461-021-03257-1. Epub 2021 Jun 15.
Biomedical research often enrolls people living with HIV (PLWH) receiving effective treatment to complete invasive procedures. This mixed methods study characterized determinants of willingness to undergo specific biomedical procedures among PLWH. In 2017, 61 participants (77% Black) from Miami completed a quantitative assessment examining willingness to participate. A subset of 19 participants completed an in-depth qualitative interview. Across all procedures, there was greater willingness to participate if asked by a primary care provider and if experimental results were shared. However, half of participants reported that they would experience undue influence (i.e., excessive persuasion) to participate from their primary care provider. In thematic analyses, altruism and personal benefit were identified as facilitators while medication changes, confidentiality, and perceived stigma were identified as barriers to participation in HIV biomedical research. Addressing participants' expectations and mitigating potential undue influence from primary care providers could optimize the ethical conduct of HIV biomedical studies.
生物医学研究经常招募接受有效治疗的艾滋病毒感染者（PLWH）来完成侵入性程序。这项混合方法研究描述了 PLWH 愿意接受特定生物医学程序的决定因素。2017 年，来自迈阿密的 61 名参与者（77%为黑人）完成了一项定量评估，考察了他们参与的意愿。19 名参与者的一部分完成了深入的定性访谈。在所有程序中，如果是由初级保健提供者提出的，并且如果分享实验结果，参与者更愿意参与。然而，一半的参与者报告说，他们的初级保健提供者会对他们施加不必要的影响（即过度劝说），让他们参与。在主题分析中，利他主义和个人利益被确定为促进因素，而药物变化、保密性和感知耻辱感被确定为参与艾滋病毒生物医学研究的障碍。满足参与者的期望并减轻初级保健提供者的潜在不当影响，可以优化艾滋病毒生物医学研究的伦理行为。
