Division of Community Internal Medicine, Mayo Clinic Jacksonville, Florida, USA.
Division of Laboratory Medicine and Pathology, Mayo Clinic Jacksonville, Florida, USA.
Immun Inflamm Dis. 2021 Dec;9(4):1146-1152. doi: 10.1002/iid3.480. Epub 2021 Jun 15.
Solid organ transplant recipients are at increased risk of acquiring devastating infections with unusual pathogens. Nocardia are aerobic actinomycetes that affect the lungs, brain, skin and soft tissue. Cladophialophora species are dematiaceous fungi that overwhelmingly cause infections in the brain. Both organisms carry a high mortality rate. We present the first reported renal transplant case with Cladophialophora bantiana involving the renal allograft with concurrent invasive nocardiosis involving the lungs and brain.
实体器官移植受者罹患罕见病原体所致严重感染的风险增加。奴卡菌属为需氧放线菌,可影响肺部、大脑、皮肤和软组织。瓶霉菌属为暗色丝孢霉,绝大多数情况下导致脑部感染。两种病原体均具有较高的死亡率。我们报告首例肾移植后感染棒状瓶霉和同时合并肺部及脑部侵袭性奴卡菌病的病例。