呼出一氧化氮分数无抑制可识别重度哮喘中对皮质类固醇耐药的2型信号传导。 - Suppr

Fractional Exhaled Nitric Oxide Nonsuppression Identifies Corticosteroid-Resistant Type 2 Signaling in Severe Asthma.

作者信息

Couillard Simon, Shrimanker Rahul, Chaudhuri Rekha, Mansur Adel H, McGarvey Lorcan P, Heaney Liam G, Fowler Stephen J, Bradding Peter, Pavord Ian D, Hinks Timothy S C

机构信息

University of Oxford Oxford, United Kingdom.

Université de Sherbrooke Sherbrooke, Quebec, Canada.

出版信息

Am J Respir Crit Care Med. 2021 Sep 15;204(6):731-734. doi: 10.1164/rccm.202104-1040LE.

DOI:10.1164/rccm.202104-1040LE

PMID:34129808

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8521703/

Abstract

摘要

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Fractional Exhaled Nitric Oxide Nonsuppression Identifies Corticosteroid-Resistant Type 2 Signaling in Severe Asthma.呼出一氧化氮分数无抑制可识别重度哮喘中对皮质类固醇耐药的2型信号传导。

Am J Respir Crit Care Med. 2021 Sep 15;204(6):731-734. doi: 10.1164/rccm.202104-1040LE.

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Exhaled nitric oxide: a test for diagnosis and control of asthma?呼出一氧化氮：一种用于哮喘诊断和控制的检测方法？

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Exhaled nitric oxide continues to reflect airway hyperresponsiveness and disease activity in inhaled corticosteroid-treated adult asthmatic patients.呼出一氧化氮仍可反映吸入糖皮质激素治疗的成年哮喘患者的气道高反应性和疾病活动情况。

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Elevated fractional exhaled nitric oxide (FeNO) is a clinical indicator of uncontrolled asthma in children receiving inhaled corticosteroids.呼出一氧化氮分数（FeNO）升高是接受吸入性糖皮质激素治疗的儿童哮喘控制不佳的临床指标。

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Fractional Exhaled Nitric Oxide Monitoring Does Not Improve Asthma Management in Children with Concordant and Discordant Asthma Phenotypes.呼出气一氧化氮分数监测并不能改善具有一致和不一致哮喘表型的儿童的哮喘管理。

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Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide.基于血液嗜酸性粒细胞和呼出气一氧化氮的哮喘发作风险原型量表的推导。

Thorax. 2022 Feb;77(2):199-202. doi: 10.1136/thoraxjnl-2021-217325. Epub 2021 Aug 6.

Baseline FeNO as a prognostic biomarker for subsequent severe asthma exacerbations in patients with uncontrolled, moderate-to-severe asthma receiving placebo in the LIBERTY ASTHMA QUEST study: a post-hoc analysis.基线呼出气一氧化氮（FeNO）作为 LIBERTY ASTHMA QUEST 研究中接受安慰剂治疗的未控制的中重度哮喘患者随后发生严重哮喘加重的预后生物标志物：一项事后分析。

Lancet Respir Med. 2021 Oct;9(10):1165-1173. doi: 10.1016/S2213-2600(21)00124-7. Epub 2021 Jun 25.

Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial.复合 2 型生物标志物策略与基于症状风险的算法调整重度哮喘患者皮质类固醇剂量：一项多中心、单盲、平行组、随机对照试验。

Lancet Respir Med. 2021 Jan;9(1):57-68. doi: 10.1016/S2213-2600(20)30397-0. Epub 2020 Sep 8.

Prognostic and Predictive Value of Blood Eosinophil Count, Fractional Exhaled Nitric Oxide, and Their Combination in Severe Asthma: A Analysis.血液嗜酸性粒细胞计数、呼出一氧化氮分数及其联合检测在重度哮喘中的预后和预测价值：一项分析。

Am J Respir Crit Care Med. 2019 Nov 15;200(10):1308-1312. doi: 10.1164/rccm.201903-0599LE.

Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Nonadherence in Severe Asthma.远程监测治疗和一氧化氮抑制可识别重度哮喘中的不依从性。

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N Engl J Med. 2018 Jun 28;378(26):2486-2496. doi: 10.1056/NEJMoa1804092. Epub 2018 May 21.

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N Engl J Med. 2017 Sep 7;377(10):936-946. doi: 10.1056/NEJMoa1704064.

Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients.利用临床生物标志物鉴定哮喘患者气道黏膜 2 型炎症。

J Allergy Clin Immunol. 2017 Sep;140(3):710-719. doi: 10.1016/j.jaci.2016.11.038. Epub 2017 Jan 13.

The utility of fractional exhaled nitric oxide suppression in the identification of nonadherence in difficult asthma.呼出气一氧化氮分数抑制在识别难治性哮喘中的应用。

Am J Respir Crit Care Med. 2012 Dec 1;186(11):1102-8. doi: 10.1164/rccm.201204-0587OC. Epub 2012 Sep 28.

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial.美泊利单抗治疗严重嗜酸性粒细胞性哮喘（DREAM）：一项多中心、双盲、安慰剂对照试验。

Lancet. 2012 Aug 18;380(9842):651-9. doi: 10.1016/S0140-6736(12)60988-X.

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Fractional Exhaled Nitric Oxide Nonsuppression Identifies Corticosteroid-Resistant Type 2 Signaling in Severe Asthma.

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