儿童使用药用大麻的疗效与安全性：一项范围综述。
Efficacy and safety of paediatric medicinal cannabis use: A scoping review.
作者信息
Pawliuk Colleen, Chau Briana, Rassekh S Rod, McKellar Terri, Siden Harold Hal
机构信息
Department of Paediatrics, BC Children's Hospital Research Institute, Vancouver, British Columbia.
Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia.
出版信息
Paediatr Child Health. 2020 Apr 30;26(4):228-233. doi: 10.1093/pch/pxaa031. eCollection 2021 Jul.
INTRODUCTION
The use of medicinal cannabis in the paediatric age group is increasing despite the lack of evidence for its efficacy or safety.
OBJECTIVE
To map the available evidence on the efficacy and safety of medicinal cannabis in children and adolescents.
METHODS
We conducted a scoping review and searched six electronic databases and grey literature. A study was eligible for inclusion when it investigated the efficacy or safety of medicinal cannabis for any condition, more than half of the participants were 0 to 18 years old, and had any study design except single case reports.
RESULTS
We included 36 studies in our final analysis, 32 of which investigated the efficacy or safety of cannabis in treatment-resistant epilepsy. The remaining 4 studies examined patients with cancer, dysautonomia, Epidermolysis Bullosa, and motor disorders.
CONCLUSIONS
There is a lack of evidence on the efficacy and safety of medicinal cannabis in most paediatric conditions.
引言
尽管缺乏药用大麻在疗效或安全性方面的证据，但在儿科年龄组中其使用仍在增加。
目的
梳理关于药用大麻在儿童和青少年中疗效和安全性的现有证据。
方法
我们进行了一项范围综述，并检索了六个电子数据库和灰色文献。当一项研究调查了药用大麻对任何病症的疗效或安全性、超过一半的参与者年龄在0至18岁之间且采用了除单病例报告之外的任何研究设计时，该研究即符合纳入条件。
结果
我们在最终分析中纳入了36项研究，其中32项研究调查了大麻在难治性癫痫治疗中的疗效或安全性。其余4项研究考察了患有癌症、自主神经功能障碍、大疱性表皮松解症和运动障碍的患者。
结论
在大多数儿科病症中，缺乏关于药用大麻疗效和安全性的证据。
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