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马来西亚沙捞越州新兴狂犬病的回顾性分析:一种被忽视的热带病。

A retrospective analysis of emerging rabies: a neglected tropical disease in Sarawak, Malaysia.

机构信息

Medical Department, Batu 5 1/2, Jalan Ulu Oya, 96000, Sibu Sarawak, Malaysia, Email:

Paediatric Department, Hospital Kuala Lumpur, Ministry of Health Malaysia, Kuala Lumpur, Malaysia.

出版信息

J R Coll Physicians Edinb. 2021 Jun;51(2):133-139. doi: 10.4997/JRCPE.2021.207.

Abstract

BACKGROUND

Rabies, a neglected tropical disease (NTD), is a viral infection which is often fatal. Since 2017, a rabies epidemic has been declared in Sarawak, Malaysia. However, there is a lack of local epidemiological data and descriptions of local presentations of this disease.

METHOD

This was a retrospective analysis of a series of rabies cases encountered in Sibu Hospital, Sarawak from March 2020 to February 2021.

RESULT

Six cases of rabies were identified in this series, all with a mixture of upper motor neuron and lower motor neuron findings. Most cases did not seek medical attention upon dog bite and therefore effective post-exposure prophylaxis was not given. The incubation period varied from 17 days to 2 years. All cases died, with five cases succumbing to the illness within two weeks of symptom onset. The cumulative incidence for rabies in Sibu was estimated at 1.7 per 100,000 population.

CONCLUSION

The lack of public awareness of the implication of animal bites and the immediate management in rabies-endemic regions are factors contributing to high rabies mortality.

摘要

背景

狂犬病是一种被忽视的热带病(NTD),是一种常见致命的病毒感染。自 2017 年以来,马来西亚沙捞越州已宣布爆发狂犬病疫情。然而,当地缺乏这种疾病的流行病学数据和临床表现的描述。

方法

这是对 2020 年 3 月至 2021 年 2 月期间在沙捞越诗巫医院遇到的一系列狂犬病病例进行的回顾性分析。

结果

本系列共发现 6 例狂犬病病例,均有上运动神经元和下运动神经元混合表现。大多数病例在被狗咬伤后没有寻求医疗救治,因此没有给予有效的暴露后预防措施。潜伏期从 17 天到 2 年不等。所有病例均死亡,其中 5 例在症状出现后两周内死亡。估计诗巫的狂犬病累积发病率为每 10 万人 1.7 例。

结论

在狂犬病流行地区,公众对动物咬伤的后果和及时处理的意识不足是导致高狂犬病死亡率的因素。

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