髋部和膝部骨关节炎与跌倒之间的关联：一项系统评价和荟萃分析。

Association between hip and knee osteoarthritis with falls: A systematic review and meta-analysis.

作者信息

Deng Zhen-Han, Xu Jian, Long Lu-Jue, Chen Fei, Chen Kang, Lu Wei, Wang Da-Ping, Peng Liang-Quan

机构信息

Department of Sports Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.

School of Medicine, Shenzhen University, Shenzhen, China.

出版信息

Int J Clin Pract. 2021 Oct;75(10):e14537. doi: 10.1111/ijcp.14537. Epub 2021 Jul 9.

DOI:10.1111/ijcp.14537

PMID:34132007

Abstract

OBJECTIVE

To examine the association between hip and knee osteoarthritis (OA) and falls. Potentially relevant articles that examine the association between hip, knee, radiological, and self-reported OA and falls were retrieved from PubMed, EMBASE, Scopus, and Web of Science up until March of 2020.

METHODS

The pooled risk ratios (RRs) as well as their related 95% confidence intervals (CIs) were calculated. Statistic and subgroup analyses were performed. A total of 21 studies involving 146 965 participants were included.

RESULTS

No association was found between hip OA and falls. The pooled RRs value suggested a higher prevalence of falls in knee OA patients (RR = 1.35, 95% CI: 1.20 to 1.51, P < .00001) and self-reported OA (RR = 1.33, 95% CI: 1.23 to 1.45, P < .00001) than in non-OA subjects. The pooled RR value suggested no difference between prevalence of falls in radiological OA patients compared to non-OA subjects (RR = 1.82, 95% CI: 0.89 to 3.73, P = .10). Both radiological and self-reported knee OA seem to be positively associated with falls, while no obvious association was found between hip OA and falls.

CONCLUSIONS

Therefore, knee OA is a risk factor for falls which should be closely monitored.

摘要

目的

研究髋部和膝部骨关节炎（OA）与跌倒之间的关联。截至2020年3月，从PubMed、EMBASE、Scopus和Web of Science数据库中检索了研究髋部、膝部、影像学诊断的和自我报告的OA与跌倒之间关联的潜在相关文章。

方法

计算合并风险比（RRs）及其相关的95%置信区间（CIs）。进行统计学和亚组分析。共纳入21项研究，涉及146965名参与者。

结果

未发现髋部OA与跌倒之间存在关联。合并RRs值表明，膝部OA患者（RR = 1.35，95% CI：1.20至1.51，P <.00001）和自我报告的OA患者（RR = 1.33，95% CI：1.23至1.45，P <.00001）的跌倒发生率高于非OA受试者。合并RRs值表明，影像学诊断的OA患者与非OA受试者相比，跌倒发生率无差异（RR = 1.82，95% CI：0.89至3.73，P = 0.10）。影像学诊断的和自我报告的膝部OA似乎都与跌倒呈正相关，而髋部OA与跌倒之间未发现明显关联。