Cho Catherine, Bak Grace, Richards Bethan, Sherrington Catherine
Concord Repatriation General Hospital, Concord, New South Wales, Australia
The University of Sydney, Sydney, New South Wales, Australia.
BMJ Open. 2025 Jul 28;15(7):e096226. doi: 10.1136/bmjopen-2024-096226.
To describe the available literature on the epidemiology and factors associated with osteoporosis, falls and fractures in four chronic inflammatory rheumatic diseases (CIRD): rheumatoid arthritis (RA); psoriatic arthritis (PsA); ankylosing spondylitis (AS); and systemic lupus erythematosus (SLE).
Scoping review, using the Joanna Briggs Institute framework.
MEDLINE, Embase and CINAHL from January 2000 to December 2023.
Observational studies reporting on the epidemiology and/or associated factors for osteoporosis, falls and fractures in RA, PsA, AS or SLE.
Two independent reviewers used a standard data extraction form including report methods, definitions, outcomes and associated factors. Results are summarised with descriptive statistics.
288 studies met inclusion criteria, with 170 studies on RA, 19 on PsA, 49 on AS and 60 on SLE. Most studies were cross-sectional, with Europe and Asia having the greatest output. Most papers reported on osteoporosis and fractures as outcomes, with only 27 reporting falls, of which 24 were in RA. Participants' demographics and disease-related parameters were the most frequently explored potential associated factors.
RA was the most well-studied CIRD with regard to the epidemiology and associated factors for osteoporosis, fractures and falls. Cross-sectional was the most common study design, with a higher proportion of cohort studies in RA. There is a paucity of studies assessing falls in CIRDs other than RA. Future observational research should be conducted with large prospective CIRD cohorts, with falls as an outcome and associated factor for fractures. This may enable better understanding of the risk and consequences of osteoporosis, fractures and falls, which may improve preventive care.
描述关于四种慢性炎症性风湿性疾病（CIRD）——类风湿关节炎（RA）、银屑病关节炎（PsA）、强直性脊柱炎（AS）和系统性红斑狼疮（SLE）——中骨质疏松症、跌倒和骨折的流行病学及相关因素的现有文献。
采用乔安娜·布里格斯研究所框架进行范围综述。
2000年1月至2023年12月的MEDLINE、Embase和CINAHL数据库。
报告RA、PsA、AS或SLE中骨质疏松症、跌倒和骨折的流行病学及/或相关因素的观察性研究。
两名独立评审员使用标准数据提取表，包括报告方法、定义、结果和相关因素。结果用描述性统计进行总结。
288项研究符合纳入标准，其中170项关于RA，19项关于PsA，49项关于AS，60项关于SLE。大多数研究为横断面研究，欧洲和亚洲的研究产出最多。大多数论文将骨质疏松症和骨折作为结果进行报告，只有27项报告了跌倒情况，其中24项是关于RA的。参与者的人口统计学和疾病相关参数是最常探讨的潜在相关因素。
就骨质疏松症、骨折和跌倒的流行病学及相关因素而言，RA是研究最多的CIRD。横断面研究是最常见的研究设计，RA中队列研究的比例较高。除RA外，评估CIRD中跌倒情况的研究较少。未来应开展大型前瞻性CIRD队列的观察性研究，将跌倒作为骨折的结果和相关因素。这可能有助于更好地理解骨质疏松症、骨折和跌倒的风险及后果，从而改善预防保健。
