Department of Mechano-Informatics, Graduate School of Information Science and Technology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Artificial Cell Membrane Systems Group, Kanagawa Institute of Industrial Science and Technology, 3-2-1 Sakado, Takatsu-ku, Kawasaki, Kanagawa 213-0012, Japan and Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.
Lab Chip. 2021 Jul 13;21(14):2643-2657. doi: 10.1039/d1lc00233c.
Biohybrid odorant sensors that directly integrate a biological olfactory system have been increasingly studied and are suggested to be the next generation of ultrasensitive sensors by taking advantage of the sensitivity and selectivity of living organisms. In this review, we provide a detailed description of the recent developments of biohybrid odorant sensors, especially considering the requisites for their perspective of on-site applications. We introduce the methodologies to effectively capture the biological signals from olfactory systems by readout devices, and describe the essential properties regarding the gaseous detection, stability, quality control, and portability. Moreover, we address the recent progress on multiple odorant recognition using multiple sensors as well as the current screening approaches for pairs of orphan receptors and ligands necessary for the extension of the currently available range of biohybrid sensors. Finally, we discuss our perspectives for the future for the development of practical odorant sensors.
生物杂交气味传感器直接集成了生物嗅觉系统，利用生物体的灵敏度和选择性，越来越受到研究关注，并被认为是下一代超高灵敏度传感器。在这篇综述中，我们详细描述了生物杂交气味传感器的最新进展，特别是考虑了其现场应用的要求。我们介绍了通过读取设备有效地从嗅觉系统中获取生物信号的方法，并描述了关于气体检测、稳定性、质量控制和便携性的基本特性。此外，我们还讨论了使用多个传感器进行多种气味识别的最新进展，以及当前用于扩展现有生物杂交传感器范围所需的孤儿受体和配体对的筛选方法。最后，我们讨论了我们对未来实用气味传感器发展的展望。
