Department of Chemistry and Life Science, United States Military Academy, West Point, NY, United States; Burke Neurological Institute, White Plains, NY, United States; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, United States.
Department of Chemistry and Life Science, United States Military Academy, West Point, NY, United States.
Biosens Bioelectron. 2019 Jan 1;123:211-222. doi: 10.1016/j.bios.2018.08.063. Epub 2018 Aug 27.
Artificial chemosensory devices have a wide range of applications in industry, security, and medicine. The development of these devices has been inspired by the speed, sensitivity, and selectivity by which the olfactory system in animals can probe the chemical nature of the environment. In this review, we examine how molecular and cellular components of natural olfactory systems have been incorporated into artificial chemosensors, or bioelectronic sensors. We focus on the biological material that has been combined with signal transduction systems to develop artificial chemosensory devices. The strengths and limitations of different biological chemosensory material at the heart of these devices, as well as the reported overall effectiveness of the different bioelectronic sensor designs, is examined. This review also discusses future directions and challenges for continuing to advance development of bioelectronic sensors.
人工化学感觉设备在工业、安全和医学领域有广泛的应用。这些设备的发展受到动物嗅觉系统探测环境化学性质的速度、灵敏度和选择性的启发。在这篇综述中，我们研究了天然嗅觉系统的分子和细胞成分如何被纳入人工化学传感器或生物电子传感器中。我们重点介绍了与信号转导系统相结合以开发人工化学感觉设备的生物材料。我们还检查了这些设备核心的不同生物化学感觉材料的优缺点，以及不同生物电子传感器设计的报告总有效性。本综述还讨论了继续推进生物电子传感器发展的未来方向和挑战。
