Department of Chemistry, Indiana University, 800 East Kirkwood, Bloomington, Indiana 47405, United States.
Department of MCD Biology, University of Colorado, 1945 Colorado Ave., Boulder, Colorado 80309, United States.
J Med Chem. 2021 Jul 8;64(13):8939-8941. doi: 10.1021/acs.jmedchem.1c00983. Epub 2021 Jun 16.
Basal glucose control is commonly maintained by a single, once-daily administration of insulin through subcutaneous injection or a continuous pump-infusion. Insulin icodec, a novel ultralong-acting lipidated analog validates the concept of a once-weekly basal injection that is less burdensome, yet equally safe and efficacious as conventional once-daily treatment.
基础血糖控制通常通过皮下注射或连续泵输注的单次每日一次胰岛素给药来维持。新型超长效脂质化类似物胰岛素icodec 验证了每周一次基础注射的概念，这种注射方式负担更小，但与常规每日一次的治疗同样安全有效。
