Faculty of Physics, Adam Mickiewicz University, Uniwersytetu Poznanskiego 2, 61-614 Poznań, Poland.
Faculty of Physics, Adam Mickiewicz University, Uniwersytetu Poznanskiego 2, 61-614 Poznań, Poland; NanoBioMedical Centre, Adam Mickiewicz University, Wszechnicy Piastowskiej 3, 61-614 Poznań, Poland.
Int J Pharm. 2021 Aug 10;605:120800. doi: 10.1016/j.ijpharm.2021.120800. Epub 2021 Jun 13.
The method of H Nuclear Magnetic Resonance (NMR) relaxometry is applied to investigate the kinetics of the recrystallization of an active pharmaceutical ingredient (felodipine) from the amorphous phase of its physical mixture with a polymer (polyvinylpyrrolidone, PVP). Comparison of the recrystallization results obtained for amorphous felodipine and its mixtures with PVP shows that the recrystallization process of API is faster in the mixtures and depends on the content of water in the system. The free induction decay (FID) for protons that were detected are composed of three components, and the loss of water from PVP strongly influences the part characterized by the longest spin-spin lattice relaxation time. Analysis of the FID of the physical mixture indicates that the content of water does not change during the recrystalization process. The study shows that the TH NMR relaxometry method is very useful for analysing the composition of a three-phase mixture and the recrystallization process.
H 核磁共振（NMR）弛豫法被应用于研究活性药物成分（非洛地平）从其与聚合物（聚乙烯吡咯烷酮，PVP）的物理混合物的无定形相的再结晶动力学。比较无定形非洛地平及其与 PVP 的混合物的再结晶结果表明，API 的再结晶过程在混合物中更快，并且取决于系统中水的含量。检测到的质子的自由感应衰减（FID）由三个分量组成，并且 PVP 中的水损失强烈影响由最长自旋-晶格弛豫时间表征的部分。物理混合物的 FID 分析表明，在再结晶过程中，水的含量没有变化。研究表明，TH NMR 弛豫法非常适用于分析三相混合物的组成和再结晶过程。
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