Faculty of Physics, Adam Mickiewicz University, Uniwersytetu Poznańskiego 2, 61-614, Poznań, Poland.
Institute Laue Langevin, 71 Avenue Des Martyrs, Grenoble, France.
AAPS PharmSciTech. 2024 Sep 19;25(7):219. doi: 10.1208/s12249-024-02919-2.
The isothermal crystallization process of felodipine has been investigated using the time-domain Nuclear Magnetic Resonance (NMR) method for amorphous bulk and ground samples. The obtained induction and crystallization times were then used to construct the time-temperature-transformation (TTT) diagram, both above and below the glass transition temperature (T). The Nose temperature was found equal to 363 K. Furthermore, the dynamics of crystalline and amorphous felodipine were compared across varying temperatures. Molecular dynamics simulations were also employed to explore the hydrogen-bond interactions and dynamic properties of both systems.
采用时域核磁共振（NMR）方法研究了非晶态块状和粉碎样品中菲洛地平的等温结晶过程。然后，使用获得的感应和结晶时间构建了时-温-转变（TTT）图，该图既在玻璃化转变温度（Tg）以上，也在玻璃化转变温度以下。发现 Nose 温度等于 363 K。此外，还比较了不同温度下菲洛地平的结晶和无定形动力学。还采用分子动力学模拟来研究两个体系的氢键相互作用和动态特性。
