胸腺切除及胸腺提取物处理大鼠体内钠、钾、胆固醇和总游离11-羟基皮质类固醇的变化
Natrium, potassium, cholesterol and total free 11-hydroxycorticosteroids variations in thymectomized and thymic extract treated rats.
作者信息
Boeru V, Manea E, Olariu M, Cristoveanu A, Socoliuc E
机构信息
C. I. Parhon Institute of Endocrinology, Bucharest, Romania.
出版信息
Endocrinologie. 1988 Apr-Jun;26(2):81-7.
The authors investigated the effect of thymectomy and TP2 thymic polypeptide extract administration on total, esterified and free cholesterol in the plasma and the adrenals, as well as on plasma Na and K and plasma free total 11-hydroxycorticosteroids. The results showed that total, esterified and free cholesterol decrease in the adrenals by 23.20%, 28.57% and 17.70% maximum respectively, in the thymectomized rat and that under the influence of the TP2 extract the values increase by 14.81%, 15.38% and 12.67%, respectively. Plasma cholesterol did not change. Thymectomy caused an increase in the plasma 11-hydroxycorticosteroids value by 13.4% and administration of the TP2 extract lowered their value by 58.11%. The plasma Na and K values did not change.
作者研究了胸腺切除术和给予TP2胸腺多肽提取物对血浆及肾上腺中总胆固醇、酯化胆固醇和游离胆固醇的影响，以及对血浆钠、钾和血浆游离总11 - 羟基皮质类固醇的影响。结果显示，在胸腺切除的大鼠中，肾上腺中的总胆固醇、酯化胆固醇和游离胆固醇分别最多可降低23.20%、28.57%和17.70%，而在TP2提取物的影响下，这些值分别增加14.81%、15.38%和12.67%。血浆胆固醇没有变化。胸腺切除术使血浆11 - 羟基皮质类固醇值增加了13.4%，而给予TP2提取物使其值降低了58.11%。血浆钠和钾的值没有变化。
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