因真性红细胞增多症导致酷似小脑肿瘤的小脑静脉血栓形成：一例报告。
Cerebellar venous thrombosis mimicking a cerebellar tumor due to polycythemia vera: a case report.
机构信息
Department of Neurology, Aerospace Center Hospital, Beijing, China.
Department of Radiology, Aerospace Center Hospital, Beijing, China.
出版信息
BMC Neurol. 2021 Jun 16;21(1):225. doi: 10.1186/s12883-021-02261-1.
BACKGROUND
Cerebral venous thrombosis (CVT) occurs rarely in the general population and is frequently associated with confused clinical findings and delayed diagnosis. Isolated cerebellar cortical vein thrombosis is a very rare phenomenon.
CASE PRESENTATION
This report describes a case with CVT, which is manifested as space-occupying lesions of the cerebellar hemisphere and mimics a cerebellar tumor at the beginning. The diagnosis of CVT was finalized given the laboratory and brain biopsy findings. The etiology may be related to polycythemia vera with Janus Kinase 2 V617F mutation.
CONCLUSION
Isolated cerebellar vein thrombosis should be considered when swelling and enhancing cerebellar lesions are detected. Polycythemia vera, especially with a positive JAK2 V617F mutation, may be a rare risk factor for CVT.
背景
脑静脉血栓（CVT）在普通人群中很少见，常伴有混乱的临床发现和延迟诊断。孤立性小脑脑静脉血栓形成是一种非常罕见的现象。
病例介绍
本报告描述了一例 CVT 病例，其表现为小脑半球占位性病变，最初类似于小脑肿瘤。基于实验室和脑部活检结果，最终诊断为 CVT。病因可能与伴有 Janus 激酶 2 V617F 突变的真性红细胞增多症有关。
结论
当发现肿胀和增强的小脑病变时，应考虑孤立性小脑静脉血栓形成。真性红细胞增多症，尤其是 JAK2 V617F 突变阳性，可能是 CVT 的罕见危险因素。
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