Yuan Yusong, Ding Xiaofang, Jing Zhengwei, Lu Hao, Yang Kun, Wang Yuanli, Xu Hailin
Department of Trauma and Orthopaedics, Peking University People's Hospital, Peking University, Beijing, China.
Diabetic Foot Treatment Centre, Peking University People's Hospital, Peking University, Beijing, China.
J Orthop Translat. 2021 May 26;29:100-105. doi: 10.1016/j.jot.2021.04.006. eCollection 2021 Jul.
Ischemic diabetic foot ulcer is one of the terminal complications of diabetes. The high amputation rate, recurrence rate, and treatment cost have caused a huge burden on patients and society. This study designed the modified tibial transverse transport (mTTT) technology to treat diabetic ischemic diabetic foot ulcers in patients with type 2 diabetes and investigated the effectiveness and safety of this technique.
This was a retrospective analysis of patients with type 2 diabetes and ischemic diabetic foot ulcers at two hospitals during January 2016-October 2019. These patients underwent mTTT surgery combined with wound debridement and vacuum sealing drainage negative pressure drainage treatment. In-hospital follow-up was performed at 1 month after the operation, while outpatient follow-up was performed at 3, 6, and 12 months after the operation. The ulcer healing time, recurrence rate, major amputation rate, and complications were analysed.
A total of 201 patients were enrolled in this study, including 107 males and 94 females (mean age: 68.3 ± 7.1 years). The wounds of all patients healed completely (mean healing time: 4.6 ± 1.6 months). There was no occurrence of major amputation, recurrence, and treatment-related complications in the patients.
mTTT can effectively and safely treat ischemic diabetic foot ulcers in patients with type 2 diabetes. This technology is an important part of the ischemic diabetic foot ulcer treatment system and warrants further research.
This study introduced a new method to treat the ischemic diabetic foot ulcer which was called modified tibial transverse transport. The promising outcomes of patients indicated that this surgical method had great potential for clinical application and was worthy of further clinical research with high evidence level.
缺血性糖尿病足溃疡是糖尿病的终末期并发症之一。高截肢率、复发率和治疗费用给患者和社会带来了巨大负担。本研究设计了改良胫骨横向骨搬移(mTTT)技术来治疗2型糖尿病患者的缺血性糖尿病足溃疡,并研究了该技术的有效性和安全性。
这是一项对2016年1月至2019年10月期间两家医院的2型糖尿病合并缺血性糖尿病足溃疡患者的回顾性分析。这些患者接受了mTTT手术联合创面清创及封闭式负压引流治疗。术后1个月进行住院随访,术后3、6和12个月进行门诊随访。分析溃疡愈合时间、复发率、大截肢率及并发症情况。
本研究共纳入201例患者,其中男性107例,女性94例(平均年龄:68.3±7.1岁)。所有患者创面均完全愈合(平均愈合时间:4.6±1.6个月)。患者未发生大截肢、复发及与治疗相关的并发症。
mTTT能有效、安全地治疗2型糖尿病患者的缺血性糖尿病足溃疡。该技术是缺血性糖尿病足溃疡治疗体系的重要组成部分,值得进一步研究。
本研究介绍了一种治疗缺血性糖尿病足溃疡的新方法,即改良胫骨横向骨搬移。患者良好的治疗效果表明该手术方法具有很大的临床应用潜力,值得开展高证据水平的进一步临床研究。