Smith C M, Burris S M, Rao G H, White J G
Department of Pediatrics, University of Minnesota Health Sciences Center, Minneapolis.
Thromb Res. 1988 Jul 1;51(1):35-44. doi: 10.1016/0049-3848(88)90280-0.
The present study has evaluated the influence of epinephrine on the resistance of platelets to aspiration into micropipettes, and the effect of epinephrine on the altered deformability of aspirin treated platelets. Unlike other platelet agonists previously studied, epinephrine stimulation did not alter platelet deformability at a concentration capable of causing platelet aggregation. Aspirin caused a dramatic decrease in the resistance of platelets to aspiration. Pretreatment of platelets with epinephrine prevented aspirin from altering platelet deformability, and exposure of platelets to epinephrine after treatment with aspirin reversed the increased deformability produced by the drug. Blockade of alpha-2 adrenergic receptors with yohimbine or clonidine prevented epinephrine antagonism of the mechanical effects of aspirin. The studies provide further evidence of the novel antagonism between epinephrine and aspirin on platelet structure and function.
本研究评估了肾上腺素对血小板被微量移液器吸入阻力的影响，以及肾上腺素对阿司匹林处理过的血小板变形性改变的影响。与先前研究的其他血小板激动剂不同，肾上腺素刺激在能够引起血小板聚集的浓度下并未改变血小板变形性。阿司匹林使血小板被吸入的阻力显著降低。用肾上腺素预处理血小板可防止阿司匹林改变血小板变形性，而在阿司匹林处理后使血小板暴露于肾上腺素可逆转该药物所产生的增加的变形性。用育亨宾或可乐定阻断α-2肾上腺素能受体会阻止肾上腺素对阿司匹林机械效应的拮抗作用。这些研究进一步证明了肾上腺素与阿司匹林在血小板结构和功能上存在新的拮抗作用。
