Sathiropas P, Marbet G A, Sahaphong S, Duckert F
Coagulation and Fibrinolysis Laboratory, Kantonsspital, Basel, Switzerland.
Thromb Res. 1988 Jul 1;51(1):55-62. doi: 10.1016/0049-3848(88)90282-4.
Our investigations have demonstrated on 10 volunteers receiving either 500 mg or 100 mg acetylsalicylic acid (ASA) that a low collagen concentration (1 microgram/ml) can best detect the aggregation defect caused by ASA. With the impedance aggregometry the mean inhibition reaches 82% and 52% with 500 mg and 100 mg ASA, respectively. Collagen at higher concentration (3 micrograms/ml) as well as ADP 10 and 25 mumol/l are less sensitive, less than 25% inhibition was recorded. These results suggest that a 1 microgram/ml concentration of collagen is adequate for the control of the ASA effect up to 6 days after intake of 100 mg. Furthermore, the von Willebrand factor (vWF) dependent platelet aggregation induced by 0.6 and 1.0 mg/ml ristocetin was clearly diminished after ASA. Therefore, a ristocetin screening test in whole blood for vWF disorder is possibly distorted when the test is performed within 6 days from ASA administration.
我们对10名分别服用500毫克或100毫克乙酰水杨酸（ASA）的志愿者进行的研究表明，低胶原蛋白浓度（1微克/毫升）能最好地检测出ASA引起的聚集缺陷。使用阻抗聚集法，500毫克和100毫克ASA的平均抑制率分别达到82%和52%。较高浓度（3微克/毫升）的胶原蛋白以及10和25微摩尔/升的ADP敏感性较低，记录到的抑制率低于25%。这些结果表明，1微克/毫升浓度的胶原蛋白足以在摄入100毫克ASA后长达6天内控制ASA的效果。此外，ASA后，由0.6和1.0毫克/毫升瑞斯托霉素诱导的血管性血友病因子（vWF）依赖性血小板聚集明显减弱。因此，在服用ASA后6天内进行全血瑞斯托霉素筛查试验以检测vWF紊乱时，结果可能会失真。
