Department of Ophthalmology and Visual Sciences, The Eye Institute, Medical College of Wisconsin, Milwaukee, Wisconsin.
Retina. 2021 Jul 1;41(7):1396-1402. doi: 10.1097/IAE.0000000000003039.
We investigated interindividual differences in the rate of change of posterior vitreous detachment (PVD) stage and vitreomacular adhesion area (VMAA). Crosssectional studies demonstrated increasing PVD stage and decreasing VMAA with age, but population-level means may mask interindividual variation in the rate of change.
We retrospectively evaluated PVD stage and VMAA in asymptomatic eyes of subjects who underwent repeated optical coherence tomography screening for high-risk medication use or isolated retinal disease in the fellow eye. A Turnbull estimator modeled changes in the PVD stage, and linear mixed models evaluated VMAA change.
We evaluated 101 eyes of 101 subjects. Seventy-six eyes remained in the same stage. Twenty-three eyes progressed to a higher stage. Modeling of longitudinal data predicts that at age 30, time to convert to Stage 4 is 26 years; at age 40, it is 16 years; at age 50, it is 9 years; and at age 60, it is 8 years. In 37 eyes with Stage 1 partial PVD, VMAA decreased at a similar rate. The average population level decline in VMAA was 0.13 mm2/year.
Individuals vary in age at which they progress to complete PVD. In early partial PVD, VMAA decreases at a similar rate across individuals.
我们研究了后玻璃体脱离（PVD）阶段和玻璃体黄斑粘连面积（VMAA）变化率的个体差异。横断面研究表明，随着年龄的增长，PVD 阶段增加，VMAA 减少，但人群平均水平可能掩盖了变化率的个体差异。
我们回顾性评估了接受重复光学相干断层扫描筛查高危药物使用或对侧眼孤立性视网膜疾病的无症状眼的 PVD 阶段和 VMAA。使用 Turnbull 估计器对 PVD 阶段的变化进行建模，并使用线性混合模型评估 VMAA 的变化。
我们评估了 101 名受试者的 101 只眼。76 只眼仍处于同一阶段。23 只眼进展到更高的阶段。纵向数据分析预测，30 岁时，进展到 4 期的时间为 26 年；40 岁时，为 16 年；50 岁时，为 9 年；60 岁时，为 8 年。在 37 只 1 期部分 PVD 眼中，VMAA 以相似的速度下降。VMAA 的平均人群水平下降率为 0.13mm²/年。
个体在进展为完全 PVD 的年龄上存在差异。在早期的部分 PVD 中，VMAA 在个体之间以相似的速度下降。
