Zhang Jia-Lu, Ye Wen-Long, Zhang Jie, Hu Xiu-Qin, Xu Peng-Fei
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Org Lett. 2021 Jul 2;23(13):5033-5038. doi: 10.1021/acs.orglett.1c01559. Epub 2021 Jun 17.
A novel approach for the asymmetric construction of polycyclic indazole skeletons via enamine-imine activation and PCET activation was developed by merging organocatalysis with photocatalysis through an asymmetric triple-reaction sequence. In this process, five C-X bonds and five consecutive chiral centers were efficiently constructed. Differently substituted polycyclic indazole deriatives were successfully constructed with satisfactory results under mild conditions.
通过将有机催化与光催化通过不对称三反应序列相结合，开发了一种通过烯胺-亚胺活化和PCET活化不对称构建多环吲唑骨架的新方法。在此过程中，高效构建了五个C-X键和五个连续的手性中心。在温和条件下成功构建了不同取代的多环吲唑衍生物，结果令人满意。
