Suzuki Yuya, Kuroda Masaru, Fujioka Tomoo, Kintsu Masayuki, Noda Tsubasa, Matsumoto Akinori, Kawata Masahito
Department of Cardiovascular Medicine Akashi Medical Center Akashi Hyogo Japan.
J Arrhythm. 2021 May 4;37(3):607-615. doi: 10.1002/joa3.12538. eCollection 2021 Jun.
Early recurrences of atrial arrhythmias (ERAAs) after ablation may require therapeutic intervention. The optimal medical therapy that prevents ERAAs requires clarification. This study aimed to compare the incidence of ERAAs between patients who received or did not receive bisoprolol transdermal patches (BTPs) at 3 months postablation.
This single-center retrospective study enrolled 203 consecutive patients with paroxysmal atrial fibrillation (AF) who had undergone their first ablation, comprising 59 in the BTP group and 144 in the non-BTP group. Follow-up assessments were conducted monthly for 3 months. We evaluated the incidence of ERAAs.
During the initial 1-week observational period, the rate of ERAAs was lower in the BTP group (5.0%) than that in the non-BTP group (18.8%) ( = .013). At 3 months postablation, the rate of ERAAs was lower in the BTP group (6.8%) than that in the non-BTP group (25.7%) ( = .002). The cumulative freedom from ERAAs was significantly lower in the BTP group than in the non-BTP group (log-rank: = .003). Administering BTPs was an independent factor that protected against ERAAs (odds ratio 0.181, [95% confidence interval 0.059-0.559], = .003).
BTPs may prevent ERAAs after ablation.
消融术后房性心律失常的早期复发（ERAA）可能需要进行治疗干预。预防ERAA的最佳药物治疗方法有待明确。本研究旨在比较消融术后3个月接受或未接受比索洛尔透皮贴剂（BTP）的患者中ERAA的发生率。
这项单中心回顾性研究纳入了203例连续接受首次消融的阵发性心房颤动（AF）患者，其中BTP组59例，非BTP组144例。进行为期3个月的每月随访评估。我们评估了ERAA的发生率。
在最初1周的观察期内，BTP组的ERAA发生率（5.0%）低于非BTP组（18.8%）（P = 0.013）。消融术后3个月，BTP组的ERAA发生率（6.8%）低于非BTP组（25.7%）（P = 0.002）。BTP组无ERAA的累积自由度显著低于非BTP组（对数秩检验：P = 0.003）。使用BTP是预防ERAA的独立因素（优势比0.181，[95%置信区间0.059 - 0.559]，P = 0.003）。
BTP可能预防消融术后的ERAA。
