Lin Jian-Yun, Cao Xi-Ying, Xiao Ying, Wang Jin-Xin, Luo Shi-He, Yang Li-Ting, Fang Yong-Gan, Wang Zhao-Yang
School of Chemistry, South China Normal University, Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, Guangzhou 510006, P. R. China.
Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 510640, P. R. China.
iScience. 2021 May 8;24(6):102518. doi: 10.1016/j.isci.2021.102518. eCollection 2021 Jun 25.
The bio-based lactic acid (LA) and the common metal ion chelating agent iminodiacetic acid (IDA) are used to design and prepare a polymeric sustained-release Pb chelating agent by a brief one-step reaction. After the analysis on theoretical calculation for this reaction, poly(lactic acid-iminodiacetic acid) [P(LA--IDA)] with different monomer molar feed ratios is synthesized via direct melt polycondensation. P(LA--IDA) mainly has star-shaped structure, and some of them have two-core or three-core structure. Thus, a possible mechanism of the polymerization is proposed. The degradation rate of P(LA--IDA)s can reach 70% in 4 weeks. The change of IDA release rate is consistent with the trend of the degradation rate, and the good Pb chelating performance is confirmed. P(LA--IDA) is expected to be developed as a lead poisoning treatment drug or Pb adsorbent in the environment with long-lasting effect, and this research provides a new strategy for the development of such drugs.
利用生物基乳酸（LA）和常见的金属离子螯合剂亚氨基二乙酸（IDA），通过简单的一步反应设计并制备了一种聚合物缓释铅螯合剂。在对该反应进行理论计算分析后，通过直接熔融缩聚合成了不同单体摩尔进料比的聚（乳酸-亚氨基二乙酸）[P(LA-IDA)]。P(LA-IDA)主要具有星形结构，其中一些具有双核或三核结构。因此，提出了一种可能的聚合机理。P(LA-IDA)在4周内的降解率可达70%。IDA释放速率的变化与降解率趋势一致，证实了其良好的铅螯合性能。P(LA-IDA)有望开发成为一种长效的铅中毒治疗药物或环境中的铅吸附剂，该研究为开发此类药物提供了一种新策略。
Zotero 插件
