B型利钠肽原水平及其在慢性高血压妊娠中的预后作用：一项来自三级护理医院的前瞻性病例对照研究。
Pro-BNP Levels and Its Prognostic Role in Chronic Hypertensive Pregnancies: A Prospective Case-Control Study From A Tertiary Care Hospital.
作者信息
Erdol Mehmet Akif, Tanacan Atakan, Eroglu Hasan, Tonyali Nazan Vanli, Erdogan Mehmet, Yucel Aykan, Yazihan Nuray, Sahin Dilek
机构信息
Department of Cardiology, Turkish Ministry of Health, Ankara City Hospital, Ankara, Turkey.
Department of Obstetrics and Gynecology, Turkish Ministry of Health, Ankara City Hospital, Ankara, Turkey.
出版信息
Hypertens Pregnancy. 2021 Aug;40(3):202-208. doi: 10.1080/10641955.2021.1939712. Epub 2021 Jun 18.
This study aimed to investigate the prognostic value of N-terminal B-type natriuretic peptide (NT-proBNP) in pregnancies with isolated chronic hypertension (HT). 34 pregnant women with chronic HT and 40normotensive controls were enrolled. The association between plasma NT-proBNP levels obtained in the first trimester and perinatal complications were evaluated. NT-proBNP levelsstrongly predicted low birth weight (AUC=0.842, p<0.001). NT-proBNP and birth weight were negatively correlated (r= -0.323, p=0.005). NT-proBNP was found to be an individual determinant of low birth weight in univariate analysis (OR:1.03; 95%CI:1.01-1.04). NT-proBNP levels can be useful to predict low birth weight in pregnancies with chronic HT.
本研究旨在探讨N端B型利钠肽原（NT-proBNP）在孤立性慢性高血压（HT）妊娠中的预后价值。纳入了34例慢性HT孕妇和40例血压正常的对照者。评估了孕早期获得的血浆NT-proBNP水平与围产期并发症之间的关联。NT-proBNP水平强烈预测低出生体重（AUC=0.842，p<0.001）。NT-proBNP与出生体重呈负相关（r=-0.323，p=0.005）。在单因素分析中，NT-proBNP被发现是低出生体重的个体决定因素（OR：1.03；95%CI：1.01-1.04）。NT-proBNP水平有助于预测慢性HT妊娠中的低出生体重。
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