在接受根治性放疗的鼻咽癌患者中，微小染色体维持蛋白（MCMs）表达的预后意义。
Prognostic importance of expression of mini-chromosome maintenance proteins (MCMs) in patients with nasopharyngeal cancer treated with curative radiotherapy.
机构信息
Necmettin Erbakan University, Meram Faculty of Medicine, Department of Radiation Oncology, Konya, Turkey.
Necmettin Erbakan University, Meram Faculty of Medicine, Department of Pathology, Konya, Turkey.
出版信息
Braz J Otorhinolaryngol. 2022 Nov-Dec;88 Suppl 4(Suppl 4):S18-S25. doi: 10.1016/j.bjorl.2021.05.012. Epub 2021 Jun 8.
OBJECTIVE
The prognostic importance of minichromosome maintenance complex expression in nasopharyngeal cancer is still unknown. We aimed to find whether minichromosome maintenance complex 2-7 expression may potentially be used to predict the prognosis of nasopharyngeal cancer patients treated with definitive radiotherapy.
METHODS
Between April 2007 and July 2020, patients with nasopharyngeal cancer treated with radiotherapy were identified. Immunohistochemical analysis was performed on formalin-fixed paraffin-embedded tissues of cases. A single pathologist analyzed the histologic specimens of all patients.
RESULTS
Totally, 67 patients were included. The median followup was 75.3 months. Higher tumor (T) stage was correlated with minichromosome maintenance complex 2 overexpression. Minichromosome maintenance complex s expression was also associated with histopathologic subgroups. According to univariate analysis, AJCC stage, histopathological subgroups, tumor response after treatment, minichromosome maintenance complex 2, 3, 5, 6 and 7 expression were the prognostic factors that predict overall survival. According to multivariate analysis minichromosome maintenance complex 7 expression was the only prognostic marker for both progression-free survival and overall survival.
CONCLUSION
The overexpression of minichromosome maintenance complex 2, 3, 5, 6 and 7 indicated bad prognosis. Minichromosome maintenance complex 7 was an independent prognostic factor for survival outcomes in nasopharyngeal cancer and may be a potential therapeutic target for treatment.
目的
微小染色体维持复合物表达在鼻咽癌中的预后意义尚不清楚。我们旨在研究微小染色体维持复合物 2-7 的表达是否可能用于预测接受根治性放疗的鼻咽癌患者的预后。
方法
在 2007 年 4 月至 2020 年 7 月期间，确定了接受放疗的鼻咽癌患者。对病例的福尔马林固定石蜡包埋组织进行免疫组织化学分析。由一位病理学家单独分析所有患者的组织学标本。
结果
共纳入 67 例患者。中位随访时间为 75.3 个月。较高的肿瘤（T）分期与微小染色体维持复合物 2 过表达相关。微小染色体维持复合物 s 的表达也与组织病理学亚组相关。根据单因素分析，AJCC 分期、组织病理学亚组、治疗后肿瘤反应、微小染色体维持复合物 2、3、5、6 和 7 的表达是预测总生存期的预后因素。根据多因素分析，微小染色体维持复合物 7 的表达是无进展生存期和总生存期的唯一预后标志物。
结论
微小染色体维持复合物 2、3、5、6 和 7 的过表达表明预后不良。微小染色体维持复合物 7 是鼻咽癌生存结果的独立预后因素，可能是治疗的潜在治疗靶点。
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