Belgian Early Warning System Drugs, Lifestyle and Chronic Diseases, Scientific Direction Epidemiology, Sciensano, Brussels, Belgium.
Laboratory for Medicines and Health Care Products, Scientific Direction of Physical and Chemical Health Risks, Sciensano, Brussels, Belgium.
Drug Test Anal. 2021 Sep;13(9):1627-1634. doi: 10.1002/dta.3113. Epub 2021 Jun 19.
This paper reports on the identification and full chemical characterization of the substance colloquially called "etonitazepyne" or "N-pyrrolidino etonitazene" (2-(4-ethoxybenzyl)-5-nitro-1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzo[d]imidazole), a potent NPS opioid of the 5-nitrobenzimidazole class. Identification of etonitazepyne was performed, on a sample purchased during routine monitoring of the drug market, using GC-MS, HRAM LC-MS/MS, H NMR, and FTIR. The chromatographic data, together with the FTIR data, indicated the presence of a highly pure compound and already indicated a benzimidazole structure. The specific benzimidazole regio-isomer was confirmed using H NMR spectroscopy, resulting in the unambiguous identification of etonitazepyne.
本文报道了一种俗称“依他佐辛”或“N-吡咯烷乙基依他佐辛”（2-(4-乙氧基苄基)-5-硝基-1-(2-(吡咯烷-1-基)乙基)-1H-苯并[d]咪唑）的物质的鉴定和全化学特征，该物质是 5-硝基苯并咪唑类的一种强效 NPS 阿片类药物。在对药物市场进行常规监测时购买的样品中，使用 GC-MS、高分辨率 AM LC-MS/MS、1H NMR 和傅里叶变换红外光谱（FTIR）进行了依他佐辛的鉴定。色谱数据，连同 FTIR 数据，表明存在高纯度化合物，并且已经表明存在苯并咪唑结构。使用 1H NMR 光谱证实了特定的苯并咪唑区域异构体，从而明确鉴定了依他佐辛。
