海湾战争疾病退伍军人急性最大运动时的血液流变学反应。
Hemorheological responses to an acute bout of maximal exercise in Veterans with Gulf War Illness.
机构信息
Airborne Hazards and Burn Pits Center of Excellence, War Related Illness and Injury Study Center, Veterans Affairs New Jersey Health Care System, East Orange, NJ, USA; New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, NJ, USA.
Airborne Hazards and Burn Pits Center of Excellence, War Related Illness and Injury Study Center, Veterans Affairs New Jersey Health Care System, East Orange, NJ, USA.
出版信息
Life Sci. 2021 Sep 1;280:119714. doi: 10.1016/j.lfs.2021.119714. Epub 2021 Jun 16.
BACKGROUND
Altered red blood cell (RBC) deformability has been reported in Veterans with Gulf War Illness (GWI) who endorse exercise-induced symptom exacerbation and fatigue. However, it is unknown whether altered RBC deformability is worsened secondary to exercise.
OBJECTIVE
To evaluate RBC deformability in response to maximal exercise in individuals with and without GWI.
METHODS
Seventeen Veterans with GWI and 11 controls performed maximal exercise and provided blood samples (pre-, immediately post- and 60-min post-exercise). We calculated RBC deformation at infinite stress (EI), shear stress for half-deformation (SS) and their ratio (SS/EI) via repeated measures ANOVA with group and time as factors.
RESULTS
A moderate interaction effect (p = 0.08, η = 0.10), large main effect for group (p = 0.02, η = 0.19) and moderate main effect for time (p = 0.20, η = 0.06) were observed for EI, but only the main effect for group reached statistical significance. Changes in SS and SS/EI over time were similar between cases and controls as were main effects.
CONCLUSIONS
Veterans with GWI had more deformable RBCs in comparison to controls that was unaffected by maximal exercise. Future studies to confirm our findings and identify associated mechanisms are warranted.
背景
患有海湾战争病（Gulf War Illness，GWI）的退伍军人报告称，红细胞（RBC）变形能力发生改变，且他们在运动后会出现症状加重和疲劳等症状。然而，目前尚不清楚 RBC 变形能力是否因运动而进一步恶化。
目的
评估患有和不患有 GWI 的个体在最大运动时 RBC 变形能力的变化。
方法
17 名患有 GWI 的退伍军人和 11 名对照者进行了最大运动，并提供了血液样本（运动前、运动后即刻和运动后 60 分钟）。我们通过重复测量方差分析，以组和时间为因素，计算红细胞在无限应力度（EI）、半变形切应力（SS）及其比值（SS/EI）下的变形能力。
结果
我们观察到 EI 存在中等强度的交互效应（p = 0.08，η = 0.10）、大的组间主要效应（p = 0.02，η = 0.19）和中等的时间主效应（p = 0.20，η = 0.06），但只有组间主要效应具有统计学意义。病例组和对照组的 SS 和 SS/EI 随时间的变化以及主要效应相似。
结论
与对照组相比，患有 GWI 的退伍军人的 RBC 变形能力更高，而最大运动对其没有影响。需要进一步的研究来证实我们的发现并确定相关机制。
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