Cai Guiyang, Yang Qing, Sun Wei
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Key Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, School of Life Sciences, China Medical University, Shenyang, China.
Cancer Cell Int. 2021 Jun 19;21(1):315. doi: 10.1186/s12935-021-02012-9.
RSF1, remodelling and spacing factor 1, is an important interphase centromere protein and is overexpressed in many types of cancers and correlated with poor overall survival. RSF1 has functions mainly in maintaining chromosome stability, facilitating DNA repair, maintaining the protein homeostasis of RSF1 and suppressing the transcription of some oncogenes when RSF1 protein is expressed at an optimal level; however, RSF1 overexpression facilitates drug resistance and cell cycle checkpoint inhibition to prompt cancer proliferation and survival. The RSF1 expression level and gene background are crucial for RSF1 functions, which may explain why RSF1 has different functions in different cancer types. This review summarizes the functional domains of RSF1, the overexpression status of RSF1 and SNF2H in cancer based on the TCGA and GTE databases, the cancer-related functions of RSF1 in interacting with H2Aub, HDAC1, CENP-A, PLK1, ATM, CENP-S, SNF2H, HB, BubR1, cyclin E1, CBP and NF-κB and the potential clinical value of RSF1, which will lay a theoretical foundation for the structural biology study of RSF1 and application of RSF1 inhibitors, truncated RSF1 proteins and SNF2H inhibitors in the treatment of RSF1-overexpressing tumours.
重塑与间距因子1（RSF1）是一种重要的间期着丝粒蛋白，在多种癌症中过表达，且与总体生存率低相关。当RSF1蛋白以最佳水平表达时，RSF1主要具有维持染色体稳定性、促进DNA修复、维持RSF1的蛋白质稳态以及抑制某些癌基因转录的功能；然而，RSF1过表达会促进耐药性和细胞周期检查点抑制，从而促使癌症增殖和存活。RSF1的表达水平和基因背景对其功能至关重要，这可能解释了为什么RSF1在不同癌症类型中具有不同功能。本综述总结了RSF1的功能结构域、基于TCGA和GTE数据库的RSF1和SNF2H在癌症中的过表达状态、RSF1与H2Aub、HDAC1、CENP-A、PLK1、ATM、CENP-S、SNF2H、HB、BubR1、细胞周期蛋白E1、CBP和NF-κB相互作用的癌症相关功能以及RSF1的潜在临床价值，这将为RSF1的结构生物学研究以及RSF1抑制剂、截短的RSF1蛋白和SNF2H抑制剂在治疗RSF1过表达肿瘤中的应用奠定理论基础。
